biostudies-literatureUnknown13Gaggl M<h4>Background</h4>The SARS-CoV-2 pandemic increased mortality and morbidity among immunocompromised populations. Vaccination is the most important preventive measure, however, its effectiveness among patients depending on maintenance immunoglobulin G (IgG) apheresis to control autoimmune disease activity is unknown. We aimed to examine the humoral immune response after mRNA-1273 Moderna^® vaccination in immunoapheresis patients.<h4>Methods</h4>We prospectively monitored SARS-CoV-2 IgG spike (S) protein antibody levels before and after each IgG (<i>exposure</i>) or lipid (LDL) apheresis (<i>controls</i>) over 12 weeks and once after 24 weeks. Primary outcome was the difference of change of SARS-CoV-2 IgG S antibody levels from vaccination until week 12, secondary outcome was the Frontiers in immunology969193https://www.ebi.ac.uk/biostudies/studies/S-EPMC9549982biostudies-literatureSARS-CoV-2 IgG spike protein antibody response in mRNA-1273 Moderna^® vaccinated patients on maintenance immunoapheresis - a cohort study.PMC9549982Strassl RGaggl MAigner CBond GSchmidt AVychytil AWagner LAschauer CSunder-Plassmann GfalseSARS-CoV-2 IgG spike protein antibody response in mRNA-1273 Moderna^® vaccinated patients on maintenance immunoapheresis - a cohort study.<h4>Background</h4>The SARS-CoV-2 pandemic increased mortality and morbidity among immunocompromised populations. Vaccination is the most important preventive measure, however, its effectiveness among patients depending on maintenance immunoglobulin G (IgG) apheresis to control autoimmune disease activity is unknown. We aimed to examine the humoral immune response after mRNA-1273 Moderna^® vaccination in immunoapheresis patients.<h4>Methods</h4>We prospectively monitored SARS-CoV-2 IgG spike (S) protein antibody levels before and after each IgG (<i>exposure</i>) or lipid (LDL) apheresis (<i>controls</i>) over 12 weeks and once after 24 weeks. Primary outcome was the difference of change of SARS-CoV-2 IgG S antibody levels from vaccination until week 12, secondary outcome was the 2022-01-01T00:00:00Z20222025-04-04T21:41:08.115Z2024-10-18T11:16:27.861ZS-EPMC95499823622592110.3389/fimmu.2022.969193