biostudies-literatureUnknown13Guo RNational Natural Science Foundation of China Science and Technology Innovation Talents in Universities of Henan ProvinceLoss of podocyte is a characteristic pathological change of diabetic nephropathy (DN) which is associated with increased proteinuria. Many studies have shown that novel inhibitors of sodium-glucose cotransporter 2 (SGLT2-is), such as dapagliflozin, exert nephroprotective effect on delaying DN progression. However, the mechanisms underlying SGLT2-associated podocyte injury are still not fully elucidated. Here, we generated streptozotocin-induced DN models and treated them with dapagliflozin to explore the possible mechanisms underlying SGLT2 regulation. Compared to mice with DN, dapagliflozin-treated mice exhibited remission of pathological lesions, including glomerular sclerosis, thickening of the glomerular basement membrane (GBM), podocyte injury in the glomeruli, and decreased nephrotoxFrontiers in pharmacology897167https://www.ebi.ac.uk/biostudies/studies/S-EPMC9550168biostudies-literatureSGLT2 inhibitors suppress epithelial-mesenchymal transition in podocytes under diabetic conditions <i>via</i> downregulating the IGF1R/PI3K pathway.PMC9550168Wang PZheng XCui WShang JGuo RZhao ZfalseSGLT2 inhibitors suppress epithelial-mesenchymal transition in podocytes under diabetic conditions <i>via</i> downregulating the IGF1R/PI3K pathway.Loss of podocyte is a characteristic pathological change of diabetic nephropathy (DN) which is associated with increased proteinuria. Many studies have shown that novel inhibitors of sodium-glucose cotransporter 2 (SGLT2-is), such as dapagliflozin, exert nephroprotective effect on delaying DN progression. However, the mechanisms underlying SGLT2-associated podocyte injury are still not fully elucidated. Here, we generated streptozotocin-induced DN models and treated them with dapagliflozin to explore the possible mechanisms underlying SGLT2 regulation. Compared to mice with DN, dapagliflozin-treated mice exhibited remission of pathological lesions, including glomerular sclerosis, thickening of the glomerular basement membrane (GBM), podocyte injury in the glomeruli, and decreased nephrotox2022-01-01T00:00:00Z20222026-06-22T03:18:54.909Z2026-06-22T03:08:41.146ZS-EPMC95501683622556910.3389/fphar.2022.897167