{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(10)"],"submitter":["Zhou M"],"pubmed_abstract":["<h4>Objective</h4>The objective was to investigate the expression of the cGAS-STING pathway-associated protein in idiopathic inflammatory myopathy (IIM) and to investigate whether it is related to myofiber atrophy/necrosis in patients with dermatomyositis and immune-mediated necrotizing myopathy.<h4>Material and methods</h4>Muscle specimens obtained by open biopsy from 26 IIM patients (14 with dermatomyositis (DM), 8 with immune-mediated necrotizing myopathy (IMNM), and 4 with other types of IIM), 4 dystrophinopathy, and 9 control patients were assessed for expression of cGAS-STING pathway members via Western blot, quantitative real-time PCR analysis (qRT-PCR), and immunochemistry. Meanwhile, analysis its location distribution througn immunochemistry.<h4>Results</h4>Compared to the control"],"journal":["Journal of clinical laboratory analysis"],"pagination":["e24631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9550984"],"repository":["biostudies-literature"],"pubmed_title":["Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy."],"pmcid":["PMC9550984"],"pubmed_authors":["Zhou M","Jiang J","Liu M","Fang Q","Zhu W","Cheng X","Zhu S","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.","description":"<h4>Objective</h4>The objective was to investigate the expression of the cGAS-STING pathway-associated protein in idiopathic inflammatory myopathy (IIM) and to investigate whether it is related to myofiber atrophy/necrosis in patients with dermatomyositis and immune-mediated necrotizing myopathy.<h4>Material and methods</h4>Muscle specimens obtained by open biopsy from 26 IIM patients (14 with dermatomyositis (DM), 8 with immune-mediated necrotizing myopathy (IMNM), and 4 with other types of IIM), 4 dystrophinopathy, and 9 control patients were assessed for expression of cGAS-STING pathway members via Western blot, quantitative real-time PCR analysis (qRT-PCR), and immunochemistry. Meanwhile, analysis its location distribution througn immunochemistry.<h4>Results</h4>Compared to the control","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T14:06:36.861Z","creation":"2024-11-09T15:11:24.428Z"},"accession":"S-EPMC9550984","cross_references":{"pubmed":["36030554"],"doi":["10.1002/jcla.24631"]}}