biostudies-literatureUnknown13Li T<b>Objective:</b> To study the mechanisms of the <i>Ligusticum chuanxiong</i> Hort.-<i>Piper longum</i> L. herbal pair (LPHP) in the treatment of migraine using network pharmacology. <b>Methods:</b> The active constituents of LPHP and their targets were searched for and screened using the Chinese Medicine System Pharmacology Database. Genes related to migraine were searched on GeneCards, Online Mendelian Inheritance in Man and other databases. Cytoscape was used to construct and combine active component-target and disease-target networks. The core target was screened by network topology analysis, and the Metascape database was used for gene ontology analysis of key targets and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis to explore the molecular mechanisms in the treFrontiers in pharmacology923188https://www.ebi.ac.uk/biostudies/studies/S-EPMC9551284biostudies-literatureExploring the pharmacological action mechanism of <i>Ligusticum Chuanxiong</i>-<i>Piper Longum</i> couplet medicines on the treatment of migraine based on network pharmacology.PMC9551284Lu MLi TZheng CLu TGuo SLu FfalseExploring the pharmacological action mechanism of <i>Ligusticum Chuanxiong</i>-<i>Piper Longum</i> couplet medicines on the treatment of migraine based on network pharmacology.<b>Objective:</b> To study the mechanisms of the <i>Ligusticum chuanxiong</i> Hort.-<i>Piper longum</i> L. herbal pair (LPHP) in the treatment of migraine using network pharmacology. <b>Methods:</b> The active constituents of LPHP and their targets were searched for and screened using the Chinese Medicine System Pharmacology Database. Genes related to migraine were searched on GeneCards, Online Mendelian Inheritance in Man and other databases. Cytoscape was used to construct and combine active component-target and disease-target networks. The core target was screened by network topology analysis, and the Metascape database was used for gene ontology analysis of key targets and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis to explore the molecular mechanisms in the tre2022-01-01T00:00:00Z20222025-04-04T22:33:42.109Z2025-02-19T03:22:58.366ZS-EPMC95512843623854810.3389/fphar.2022.923188