{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Duhen R"],"pubmed_abstract":["To prevent SARS-CoV-2 infections and generate long-lasting immunity, vaccines need to generate strong viral-specific B and T cell responses. Previous results from our lab and others have shown that immunizations in the presence of an OX40 agonist antibody lead to higher antibody titers and increased numbers of long-lived antigen-specific CD4 and CD8 T cells. Using a similar strategy, we explored the effect of OX40 co-stimulation in a prime and boost vaccination scheme using an adjuvanted SARS-CoV-2 spike protein vaccine in C57BL/6 mice. Our results show that OX40 engagement during vaccination significantly increases long-lived antibody responses to the spike protein. In addition, after immunization spike protein-specific proliferation was greatly increased for both CD4 and CD8 T cells, wit"],"journal":["Frontiers in immunology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9551348"],"repository":["biostudies-literature"],"pubmed_title":["OX40 agonist stimulation increases and sustains humoral and cell-mediated responses to SARS-CoV-2 protein and saRNA vaccines"],"pmcid":["PMC9551348"],"pubmed_authors":["Abraham S","Weinberg A","Jain N","Duhen R","Thomas A","Hu H","Jensen S","Geall A","Abbina S","Beymer M","Fox B"],"additional_accession":[]},"is_claimable":false,"name":"OX40 agonist stimulation increases and sustains humoral and cell-mediated responses to SARS-CoV-2 protein and saRNA vaccines","description":"To prevent SARS-CoV-2 infections and generate long-lasting immunity, vaccines need to generate strong viral-specific B and T cell responses. Previous results from our lab and others have shown that immunizations in the presence of an OX40 agonist antibody lead to higher antibody titers and increased numbers of long-lived antigen-specific CD4 and CD8 T cells. Using a similar strategy, we explored the effect of OX40 co-stimulation in a prime and boost vaccination scheme using an adjuvanted SARS-CoV-2 spike protein vaccine in C57BL/6 mice. Our results show that OX40 engagement during vaccination significantly increases long-lived antibody responses to the spike protein. In addition, after immunization spike protein-specific proliferation was greatly increased for both CD4 and CD8 T cells, wit","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-29T11:01:54.841Z","creation":"2025-02-19T01:02:10.136Z"},"accession":"S-EPMC9551348","cross_references":{}}