biostudies-literatureUnknown9Eow SY<h4>Background</h4>The microbiota plays a key role in early immunity maturation that affects infant health and is associated with the development of non-communicable diseases and allergies in later life.<h4>Objective</h4>The MYBIOTA is a prospective mother-infant cohort study in Malaysia aiming to determine the association between gut microbiota with infant health (temperament, gastrointestinal disorders, eczema, asthma, and developmental delays) in Selangor, Malaysia.<h4>Methods</h4>Pregnant mothers will be enrolled in their first trimester of pregnancy, and follow-ups will be done for infants during their first year of life. Maternal-infant biological samples (blood, feces, saliva, urine, and breast milk), anthropometric, dietary, and clinical information will be collected at different time points from early pregnancy to 12 months postpartum.<h4>Discussion</h4>This study could provide a better understanding of the colonization and development of the gut microbiome during early life and its impact on infant health.<h4>Clinical trial registration</h4>https://clinicaltrials.gov/, identifier NCT04919265.Frontiers in nutrition994607https://www.ebi.ac.uk/biostudies/studies/S-EPMC9552002biostudies-literatureMYBIOTA: A birth cohort on maternal and infant microbiota and its impact on infant health in Malaysia.PMC9552002Liu YChin YSLoh SPChen LEow SYThong PLJiang TThan LTLLee LJHow KNZhao JGan WYfalseMYBIOTA: A birth cohort on maternal and infant microbiota and its impact on infant health in Malaysia.<h4>Background</h4>The microbiota plays a key role in early immunity maturation that affects infant health and is associated with the development of non-communicable diseases and allergies in later life.<h4>Objective</h4>The MYBIOTA is a prospective mother-infant cohort study in Malaysia aiming to determine the association between gut microbiota with infant health (temperament, gastrointestinal disorders, eczema, asthma, and developmental delays) in Selangor, Malaysia.<h4>Methods</h4>Pregnant mothers will be enrolled in their first trimester of pregnancy, and follow-ups will be done for infants during their first year of life. Maternal-infant biological samples (blood, feces, saliva, urine, and breast milk), anthropometric, dietary, and clinical information will be collected at different time points from early pregnancy to 12 months postpartum.<h4>Discussion</h4>This study could provide a better understanding of the colonization and development of the gut microbiome during early life and its impact on infant health.<h4>Clinical trial registration</h4>https://clinicaltrials.gov/, identifier NCT04919265.2022-01-01T00:00:00Z20222025-04-04T22:31:58.212Z2025-02-19T03:23:08.834ZS-EPMC95520023623846510.3389/fnut.2022.994607