biostudies-literatureUnknown16Fu ZThe starvation therapy mediated by the lonidamine (LND) was limited by the low drug delivery efficiency, off-target effect and compensative glutamine metabolism. Herein, a hyaluronic acid (HA)-modified reduction-responsive micellar nanosystem co-loaded with glycolysis and glutamine metabolism inhibitor (LND and bis-2-(5-phenylacetmido-1,2,4-thiadiazol-2-yl)ethyl sulfide, BPTES) was constructed for tumor-targeted dual-starvation therapy. The in vitro and in vivo results collectively suggested that the fabricated nanosystem could effectively endocytosed by tumor cells via HA receptor-ligand recognition, and rapidly release starvation-inducers LND and BPTES in response to the GSH-rich intratumoral cytoplasm. Furthermore, the released LND and BPTES were capable of inducing glycolysis and glutaMaterials today. Biohttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9552111biostudies-literatureTumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTESPMC9552111Yang HLi XMeng SZheng XDai LYao MZhao PFu ZDu HCai KYuan ZfalseTumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTESThe starvation therapy mediated by the lonidamine (LND) was limited by the low drug delivery efficiency, off-target effect and compensative glutamine metabolism. Herein, a hyaluronic acid (HA)-modified reduction-responsive micellar nanosystem co-loaded with glycolysis and glutamine metabolism inhibitor (LND and bis-2-(5-phenylacetmido-1,2,4-thiadiazol-2-yl)ethyl sulfide, BPTES) was constructed for tumor-targeted dual-starvation therapy. The in vitro and in vivo results collectively suggested that the fabricated nanosystem could effectively endocytosed by tumor cells via HA receptor-ligand recognition, and rapidly release starvation-inducers LND and BPTES in response to the GSH-rich intratumoral cytoplasm. Furthermore, the released LND and BPTES were capable of inducing glycolysis and gluta2022-01-01T00:00:00Z2022 Oct2025-04-29T10:59:31.152Z2025-02-19T01:01:56.67ZS-EPMC9552111