{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Griffiths OM"],"funding":["American Chemical Society","Engineering and Physical Sciences Research Council"],"pagination":["13204-13223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9552240"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["87(19)"],"pubmed_abstract":["<i>N</i>-heterospirocycles are interesting structural units found in both natural products and medicinal compounds but have relatively few reliable methods for their synthesis. Here, we enlist the photocatalytic generation of <i>N</i>-centered radicals to construct β-spirocyclic pyrrolidines from <i>N</i>-allylsulfonamides and alkenes. A variety of β-spirocyclic pyrrolidines have been constructed, including drug derivatives, in moderate to very good yields. Further derivatization of the products has also been demonstrated as has a viable scale-up procedure, making use of flow chemistry techniques."],"journal":["The Journal of organic chemistry"],"pubmed_title":["Multicomponent Direct Assembly of <i>N</i>-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis."],"pmcid":["PMC9552240"],"funding_grant_id":["EP/ S024220/1"],"pubmed_authors":["Ley SV","Griffiths OM"],"additional_accession":[]},"is_claimable":false,"name":"Multicomponent Direct Assembly of <i>N</i>-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis.","description":"<i>N</i>-heterospirocycles are interesting structural units found in both natural products and medicinal compounds but have relatively few reliable methods for their synthesis. Here, we enlist the photocatalytic generation of <i>N</i>-centered radicals to construct β-spirocyclic pyrrolidines from <i>N</i>-allylsulfonamides and alkenes. A variety of β-spirocyclic pyrrolidines have been constructed, including drug derivatives, in moderate to very good yields. Further derivatization of the products has also been demonstrated as has a viable scale-up procedure, making use of flow chemistry techniques.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-29T11:02:34.085Z","creation":"2025-04-06T19:47:45.634Z"},"accession":"S-EPMC9552240","cross_references":{"pubmed":["36103403"],"doi":["10.1021/acs.joc.2c01684"]}}