biostudies-literatureGriffiths OMAmerican Chemical SocietyEngineering and Physical Sciences Research Council13204-13223https://www.ebi.ac.uk/biostudies/studies/S-EPMC9552240biostudies-literatureUnknown87(19)<i>N</i>-heterospirocycles are interesting structural units found in both natural products and medicinal compounds but have relatively few reliable methods for their synthesis. Here, we enlist the photocatalytic generation of <i>N</i>-centered radicals to construct β-spirocyclic pyrrolidines from <i>N</i>-allylsulfonamides and alkenes. A variety of β-spirocyclic pyrrolidines have been constructed, including drug derivatives, in moderate to very good yields. Further derivatization of the products has also been demonstrated as has a viable scale-up procedure, making use of flow chemistry techniques.The Journal of organic chemistryMulticomponent Direct Assembly of <i>N</i>-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis.PMC9552240EP/ S024220/1Ley SVGriffiths OMfalseMulticomponent Direct Assembly of <i>N</i>-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis.<i>N</i>-heterospirocycles are interesting structural units found in both natural products and medicinal compounds but have relatively few reliable methods for their synthesis. Here, we enlist the photocatalytic generation of <i>N</i>-centered radicals to construct β-spirocyclic pyrrolidines from <i>N</i>-allylsulfonamides and alkenes. A variety of β-spirocyclic pyrrolidines have been constructed, including drug derivatives, in moderate to very good yields. Further derivatization of the products has also been demonstrated as has a viable scale-up procedure, making use of flow chemistry techniques.2022-01-01T00:00:00Z2022 Oct2025-04-29T11:02:34.085Z2025-04-06T19:47:45.634ZS-EPMC95522403610340310.1021/acs.joc.2c01684