{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Hu S"],"pubmed_abstract":["Oxidative stress is considered as an important mechanism underlying the pathology of neurodegenerative disorders. In this study, we utilized an <i>in vitro</i> model where oxidative stress process was evoked by exogenous hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in HT22 murine hippocampal neurons and evaluated the neuroprotective effects of geissoschizine methyl ether (GME), a naturally occurring alkaloid from the hooks of <i>Uncaria rhynchophylla</i> (Miq.) Jacks. After a 24 h H<sub>2</sub>O<sub>2</sub> (350 μM) insult, a significant decrease in cell survival and a sharp increase in intracellular reactive oxygen species were observed in HT22 cells. Encouragingly, GME (10-200 μM) effectively reversed these abnormal cellular changes induced by H<sub>2</sub>O<sub>2</sub>. Moreover, mech"],"journal":["Translational neuroscience"],"pagination":["369-378"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9552775"],"repository":["biostudies-literature"],"pubmed_title":["Protection against H<sub>2</sub>O<sub>2</sub>-evoked toxicity in HT22 hippocampal neuronal cells by geissoschizine methyl ether via inhibiting ERK pathway."],"pmcid":["PMC9552775"],"pubmed_authors":["Wen X","Wu Z","Hu S","Li Z","Yang L","Ma Y","Li L"],"additional_accession":[]},"is_claimable":false,"name":"Protection against H<sub>2</sub>O<sub>2</sub>-evoked toxicity in HT22 hippocampal neuronal cells by geissoschizine methyl ether via inhibiting ERK pathway.","description":"Oxidative stress is considered as an important mechanism underlying the pathology of neurodegenerative disorders. In this study, we utilized an <i>in vitro</i> model where oxidative stress process was evoked by exogenous hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in HT22 murine hippocampal neurons and evaluated the neuroprotective effects of geissoschizine methyl ether (GME), a naturally occurring alkaloid from the hooks of <i>Uncaria rhynchophylla</i> (Miq.) Jacks. After a 24 h H<sub>2</sub>O<sub>2</sub> (350 μM) insult, a significant decrease in cell survival and a sharp increase in intracellular reactive oxygen species were observed in HT22 cells. Encouragingly, GME (10-200 μM) effectively reversed these abnormal cellular changes induced by H<sub>2</sub>O<sub>2</sub>. Moreover, mech","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-06-01T01:16:39.084Z","creation":"2024-11-13T21:57:11.971Z"},"accession":"S-EPMC9552775","cross_references":{"pubmed":["36304098"],"doi":["10.1515/tnsci-2022-0243"]}}