{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(19)"],"submitter":["Luguera Ruiz A"],"pubmed_abstract":["There is an urgent need to develop uncharged radical precursors to be activated under mild photocatalyzed conditions. 2-Substituted-1,3-oxazolidines (<i>E</i> <sub>ox</sub> < 1.3 V vs SCE, smoothly prepared from the corresponding aldehydes) have been herein employed for the successful release of tertiary, α-oxy, and α-amido radicals under photo-organo redox catalysis. The reaction relies on the unprecedented C-C cleavage occurring from the radical cation of these heterocyclic derivatives. Such a protocol is applied to the visible-light-driven conjugate radical addition onto Michael acceptors and vinyl (hetero)arenes under mild metal-free conditions."],"journal":["ACS catalysis"],"pagination":["12469-12476"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9552967"],"repository":["biostudies-literature"],"pubmed_title":["Alkyl Radical Generation via C-C Bond Cleavage in 2-Substituted Oxazolidines."],"pmcid":["PMC9552967"],"pubmed_authors":["Protti S","Merli D","Fagnoni M","La Mantia M","Luguera Ruiz A"],"additional_accession":[]},"is_claimable":false,"name":"Alkyl Radical Generation via C-C Bond Cleavage in 2-Substituted Oxazolidines.","description":"There is an urgent need to develop uncharged radical precursors to be activated under mild photocatalyzed conditions. 2-Substituted-1,3-oxazolidines (<i>E</i> <sub>ox</sub> < 1.3 V vs SCE, smoothly prepared from the corresponding aldehydes) have been herein employed for the successful release of tertiary, α-oxy, and α-amido radicals under photo-organo redox catalysis. The reaction relies on the unprecedented C-C cleavage occurring from the radical cation of these heterocyclic derivatives. Such a protocol is applied to the visible-light-driven conjugate radical addition onto Michael acceptors and vinyl (hetero)arenes under mild metal-free conditions.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T19:32:02.464Z","creation":"2025-04-07T07:16:01.967Z"},"accession":"S-EPMC9552967","cross_references":{"pubmed":["36249874"],"doi":["10.1021/acscatal.2c03768"]}}