biostudies-literatureUnknown12(19)Luguera Ruiz AThere is an urgent need to develop uncharged radical precursors to be activated under mild photocatalyzed conditions. 2-Substituted-1,3-oxazolidines (<i>E</i> _ox < 1.3 V vs SCE, smoothly prepared from the corresponding aldehydes) have been herein employed for the successful release of tertiary, α-oxy, and α-amido radicals under photo-organo redox catalysis. The reaction relies on the unprecedented C-C cleavage occurring from the radical cation of these heterocyclic derivatives. Such a protocol is applied to the visible-light-driven conjugate radical addition onto Michael acceptors and vinyl (hetero)arenes under mild metal-free conditions.ACS catalysis12469-12476https://www.ebi.ac.uk/biostudies/studies/S-EPMC9552967biostudies-literatureAlkyl Radical Generation via C-C Bond Cleavage in 2-Substituted Oxazolidines.PMC9552967Protti SMerli DFagnoni MLa Mantia MLuguera Ruiz AfalseAlkyl Radical Generation via C-C Bond Cleavage in 2-Substituted Oxazolidines.There is an urgent need to develop uncharged radical precursors to be activated under mild photocatalyzed conditions. 2-Substituted-1,3-oxazolidines (<i>E</i> _ox < 1.3 V vs SCE, smoothly prepared from the corresponding aldehydes) have been herein employed for the successful release of tertiary, α-oxy, and α-amido radicals under photo-organo redox catalysis. The reaction relies on the unprecedented C-C cleavage occurring from the radical cation of these heterocyclic derivatives. Such a protocol is applied to the visible-light-driven conjugate radical addition onto Michael acceptors and vinyl (hetero)arenes under mild metal-free conditions.2022-01-01T00:00:00Z2022 Oct2025-04-18T19:32:02.464Z2025-04-07T07:16:01.967ZS-EPMC95529673624987410.1021/acscatal.2c03768