biostudies-literatureUnknown13Bhuiyan TRCoronavirus disease 2019 (COVID-19) is a protean disease causing different degrees of clinical severity including fatality. In addition to humoral immunity, antigen-specific T cells may play a critical role in defining the protective immune response against SARS-CoV-2, the virus that causes this disease. As a part of a longitudinal cohort study in Bangladesh to investigate B and T cell-specific immune responses, we sought to evaluate the activation-induced marker (AIM) and the status of different immune cell subsets during a COVID-19 infection. We analyzed a total of 115 participants, which included participants with asymptomatic, mild, moderate, and severe clinical symptoms. We observed decreased mucosal-associated invariant T (MAIT) cell frequency on the initial days of the COVID-19 infeFrontiers in immunology929849https://www.ebi.ac.uk/biostudies/studies/S-EPMC9554593biostudies-literatureCorrelation of antigen-specific immune response with disease severity among COVID-19 patients in Bangladesh.PMC9554593Islam SSumon MASette AQadri FBhuiyan TRAkter AAhmed TRashed AChowdhury FKarmakar PCHakim AClemens JDHasnat MAGhosh SWeiskopf DBanu SAl Banna HShirin TTauheed IKaisar MHfalseCorrelation of antigen-specific immune response with disease severity among COVID-19 patients in Bangladesh.Coronavirus disease 2019 (COVID-19) is a protean disease causing different degrees of clinical severity including fatality. In addition to humoral immunity, antigen-specific T cells may play a critical role in defining the protective immune response against SARS-CoV-2, the virus that causes this disease. As a part of a longitudinal cohort study in Bangladesh to investigate B and T cell-specific immune responses, we sought to evaluate the activation-induced marker (AIM) and the status of different immune cell subsets during a COVID-19 infection. We analyzed a total of 115 participants, which included participants with asymptomatic, mild, moderate, and severe clinical symptoms. We observed decreased mucosal-associated invariant T (MAIT) cell frequency on the initial days of the COVID-19 infe2022-01-01T00:00:00Z20222025-04-18T22:52:36.027Z2025-04-07T10:38:22.065ZS-EPMC95545933624888210.3389/fimmu.2022.929849