{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chow LS"],"funding":["NIA NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS","National Institute for Health Research (NIHR)","NNF Center for Basic Metabolic Research","NIAMS NIH HHS","Novo Nordisk Fonden"],"pagination":["273-289"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9554896"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(5)"],"pubmed_abstract":["The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. Since the discovery in 2000 that muscle contraction releases IL-6, the number of exercise-associated signalling molecules that have been identified has multiplied. Exerkines are defined as signalling moieties released in response to acute and/or chronic exercise, which exert their effects through endocrine, paracrine and/or autocrine pathways. A multitude of organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tis"],"journal":["Nature reviews. Endocrinology"],"pubmed_title":["Exerkines in health, resilience and disease."],"pmcid":["PMC9554896"],"funding_grant_id":["R03 AG067960","U01 AR071133","R01 HL138738","R01 HL165786","R01 DK098203","NNF17OC0030088","P30 DK020572","K23 HL150327","R01 AG060542","CBMR - 001","R01 HL142879","P30 DK040561","U54 DK102556","U24 DK112348"],"pubmed_authors":["Gerszten RE","Stanford KI","Lanza IR","Galis ZS","Watt MJ","Moro C","Chow LS","Goodpaster BH","Xia A","van Praag H","Snyder MP","Pandey A","Pedersen BK","Haus JM","Villeda S","Robbins JM","Lavie CJ","Febbraio MA","Taylor JM","Lee CH","Lucia A","Zierath JR","Trappe S","Gao Y","Thackray AE"],"additional_accession":[]},"is_claimable":false,"name":"Exerkines in health, resilience and disease.","description":"The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. Since the discovery in 2000 that muscle contraction releases IL-6, the number of exercise-associated signalling molecules that have been identified has multiplied. Exerkines are defined as signalling moieties released in response to acute and/or chronic exercise, which exert their effects through endocrine, paracrine and/or autocrine pathways. A multitude of organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tis","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-27T22:41:34.663Z","creation":"2024-12-03T17:06:59.398Z"},"accession":"S-EPMC9554896","cross_references":{"pubmed":["35304603"],"doi":["10.1038/s41574-022-00641-2"]}}