{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(9)"],"submitter":["Chen M"],"pubmed_abstract":["<h4>Objective</h4>Epilepsy is a common central nervous system disorder with pathological mechanisms including inflammation, ion channel impairment, and neurotransmitter imbalance. Despite the rapid development of current anti-epileptic drugs, epilepsy is not well controlled, so there is still a need for research on the mechanisms and new drug targets for epilepsy. CXCL14 is a member of the CXC family of chemokines, and its receptor is currently unknown. Chemokines are the third major communication mediators in the central nervous system and play a role in many diseases. Therefore, we explore the expression of CXCL14 in epilepsy and its possible mechanisms.<h4>Materials and methods</h4>We chose the kainic acid (KA) mouse model as the epilepsy model, and studied the expression of CXCL14 in t"],"journal":["American journal of translational research"],"pagination":["6222-6233"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9556486"],"repository":["biostudies-literature"],"pubmed_title":["CXCL14 exacerbates seizures by inhibiting GABA metabolism in epileptic mice."],"pmcid":["PMC9556486"],"pubmed_authors":["Ding X","Cao X","Chen M","He W","Wang S","Tan J","Jiang G","Zhang M"],"additional_accession":[]},"is_claimable":false,"name":"CXCL14 exacerbates seizures by inhibiting GABA metabolism in epileptic mice.","description":"<h4>Objective</h4>Epilepsy is a common central nervous system disorder with pathological mechanisms including inflammation, ion channel impairment, and neurotransmitter imbalance. Despite the rapid development of current anti-epileptic drugs, epilepsy is not well controlled, so there is still a need for research on the mechanisms and new drug targets for epilepsy. CXCL14 is a member of the CXC family of chemokines, and its receptor is currently unknown. Chemokines are the third major communication mediators in the central nervous system and play a role in many diseases. Therefore, we explore the expression of CXCL14 in epilepsy and its possible mechanisms.<h4>Materials and methods</h4>We chose the kainic acid (KA) mouse model as the epilepsy model, and studied the expression of CXCL14 in t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T22:38:41.942Z","creation":"2025-04-07T10:26:10.499Z"},"accession":"S-EPMC9556486","cross_references":{"pubmed":["36247285"]}}