biostudies-literatureUnknown14(9)Chen M<h4>Objective</h4>Epilepsy is a common central nervous system disorder with pathological mechanisms including inflammation, ion channel impairment, and neurotransmitter imbalance. Despite the rapid development of current anti-epileptic drugs, epilepsy is not well controlled, so there is still a need for research on the mechanisms and new drug targets for epilepsy. CXCL14 is a member of the CXC family of chemokines, and its receptor is currently unknown. Chemokines are the third major communication mediators in the central nervous system and play a role in many diseases. Therefore, we explore the expression of CXCL14 in epilepsy and its possible mechanisms.<h4>Materials and methods</h4>We chose the kainic acid (KA) mouse model as the epilepsy model, and studied the expression of CXCL14 in tAmerican journal of translational research6222-6233https://www.ebi.ac.uk/biostudies/studies/S-EPMC9556486biostudies-literatureCXCL14 exacerbates seizures by inhibiting GABA metabolism in epileptic mice.PMC9556486Ding XCao XChen MHe WWang STan JJiang GZhang MfalseCXCL14 exacerbates seizures by inhibiting GABA metabolism in epileptic mice.<h4>Objective</h4>Epilepsy is a common central nervous system disorder with pathological mechanisms including inflammation, ion channel impairment, and neurotransmitter imbalance. Despite the rapid development of current anti-epileptic drugs, epilepsy is not well controlled, so there is still a need for research on the mechanisms and new drug targets for epilepsy. CXCL14 is a member of the CXC family of chemokines, and its receptor is currently unknown. Chemokines are the third major communication mediators in the central nervous system and play a role in many diseases. Therefore, we explore the expression of CXCL14 in epilepsy and its possible mechanisms.<h4>Materials and methods</h4>We chose the kainic acid (KA) mouse model as the epilepsy model, and studied the expression of CXCL14 in t2022-01-01T00:00:00Z20222025-04-18T22:38:41.942Z2025-04-07T10:26:10.499ZS-EPMC955648636247285