biostudies-literatureUnknown9Ge RFew studies have investigated the encapsulation of apigenin in solid particle-stabilized emulsions. In this work, Pickering emulsions containing apigenin and stabilized by whey protein isolate-chitosan (WPI-CS) complexes were created to enhance the bioavailability of apigenin. Different lipids including medium-chain triglycerides (MCTs), ethyl oleate (EO), and corn oil (CO) were selected to fabricate lipid-based delivery systems. The microstructure of the Pickering emulsions, as revealed by optical and cryo-scanning electron microscopies, showed that the oil droplets were dispersed evenly and trapped by a three-dimensional network formed by the WPI-CS complexes, which was further confirmed by rheology properties. After 30 days of storage, Pickering emulsions with MCTs achieved the highest Frontiers in nutrition997706https://www.ebi.ac.uk/biostudies/studies/S-EPMC9556715biostudies-literatureStorage stability and <i>in vitro</i> digestion of apigenin encapsulated in Pickering emulsions stabilized by whey protein isolate-chitosan complexes.PMC9556715Ge RZhu HWang HZhong JTao NfalseStorage stability and <i>in vitro</i> digestion of apigenin encapsulated in Pickering emulsions stabilized by whey protein isolate-chitosan complexes.Few studies have investigated the encapsulation of apigenin in solid particle-stabilized emulsions. In this work, Pickering emulsions containing apigenin and stabilized by whey protein isolate-chitosan (WPI-CS) complexes were created to enhance the bioavailability of apigenin. Different lipids including medium-chain triglycerides (MCTs), ethyl oleate (EO), and corn oil (CO) were selected to fabricate lipid-based delivery systems. The microstructure of the Pickering emulsions, as revealed by optical and cryo-scanning electron microscopies, showed that the oil droplets were dispersed evenly and trapped by a three-dimensional network formed by the WPI-CS complexes, which was further confirmed by rheology properties. After 30 days of storage, Pickering emulsions with MCTs achieved the highest 2022-01-01T00:00:00Z20222025-04-18T22:37:50.556Z2025-04-07T10:25:16.941ZS-EPMC95567153624552210.3389/fnut.2022.997706