{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(10)"],"submitter":["Gao W"],"pubmed_abstract":["The identification, uptake, and clearance of nanoparticles (NPs) by phagocytes are critical in NP-based therapeutics. The cell membrane coating technique has recently emerged as an ideal surface modification approach to help NP bypass phagocytosis. CD47, a regulatory protein for phagocytosis, is a cell surface glycoprotein expressed on all cell types, including platelets. Herein, we enclosed bioactive glass (BG) with a platelet membrane to bestow BG with unique cell surface functions for immune evasion and immunomodulation. Compared with the uncoated particles, platelet membrane-coated BG shows reduced cellular uptake and can generate an immune environment favorable for osteogenesis. This is evidenced by the triggering of robust osteogenic differentiation in bone mesenchymal stromal cells,"],"journal":["iScience"],"pagination":["105196"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9556914"],"repository":["biostudies-literature"],"pubmed_title":["Targeting macrophage endocytosis via platelet membrane coating for advanced osteoimmunomodulation."],"pmcid":["PMC9556914"],"pubmed_authors":["Xiao L","Mu Y","Xiao Y","Gao W"],"additional_accession":[]},"is_claimable":false,"name":"Targeting macrophage endocytosis via platelet membrane coating for advanced osteoimmunomodulation.","description":"The identification, uptake, and clearance of nanoparticles (NPs) by phagocytes are critical in NP-based therapeutics. The cell membrane coating technique has recently emerged as an ideal surface modification approach to help NP bypass phagocytosis. CD47, a regulatory protein for phagocytosis, is a cell surface glycoprotein expressed on all cell types, including platelets. Herein, we enclosed bioactive glass (BG) with a platelet membrane to bestow BG with unique cell surface functions for immune evasion and immunomodulation. Compared with the uncoated particles, platelet membrane-coated BG shows reduced cellular uptake and can generate an immune environment favorable for osteogenesis. This is evidenced by the triggering of robust osteogenic differentiation in bone mesenchymal stromal cells,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T22:35:57.019Z","creation":"2025-04-07T10:20:18.953Z"},"accession":"S-EPMC9556914","cross_references":{"pubmed":["36248744"],"doi":["10.1016/j.isci.2022.105196"]}}