biostudies-literatureUnknown25(10)Gao WThe identification, uptake, and clearance of nanoparticles (NPs) by phagocytes are critical in NP-based therapeutics. The cell membrane coating technique has recently emerged as an ideal surface modification approach to help NP bypass phagocytosis. CD47, a regulatory protein for phagocytosis, is a cell surface glycoprotein expressed on all cell types, including platelets. Herein, we enclosed bioactive glass (BG) with a platelet membrane to bestow BG with unique cell surface functions for immune evasion and immunomodulation. Compared with the uncoated particles, platelet membrane-coated BG shows reduced cellular uptake and can generate an immune environment favorable for osteogenesis. This is evidenced by the triggering of robust osteogenic differentiation in bone mesenchymal stromal cells,iScience105196https://www.ebi.ac.uk/biostudies/studies/S-EPMC9556914biostudies-literatureTargeting macrophage endocytosis via platelet membrane coating for advanced osteoimmunomodulation.PMC9556914Xiao LMu YXiao YGao WfalseTargeting macrophage endocytosis via platelet membrane coating for advanced osteoimmunomodulation.The identification, uptake, and clearance of nanoparticles (NPs) by phagocytes are critical in NP-based therapeutics. The cell membrane coating technique has recently emerged as an ideal surface modification approach to help NP bypass phagocytosis. CD47, a regulatory protein for phagocytosis, is a cell surface glycoprotein expressed on all cell types, including platelets. Herein, we enclosed bioactive glass (BG) with a platelet membrane to bestow BG with unique cell surface functions for immune evasion and immunomodulation. Compared with the uncoated particles, platelet membrane-coated BG shows reduced cellular uptake and can generate an immune environment favorable for osteogenesis. This is evidenced by the triggering of robust osteogenic differentiation in bone mesenchymal stromal cells,2022-01-01T00:00:00Z2022 Oct2025-04-18T22:35:57.019Z2025-04-07T10:20:18.953ZS-EPMC95569143624874410.1016/j.isci.2022.105196