{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["66"],"submitter":["Cercillieux A"],"pubmed_abstract":["<h4>Objective</h4>Disturbances in NAD<sup>+</sup> metabolism have been described as a hallmark for multiple metabolic and age-related diseases, including type 2 diabetes. While alterations in pancreatic β-cell function are critical determinants of whole-body glucose homeostasis, the role of NAD<sup>+</sup> metabolism in the endocrine pancreas remains poorly explored. Here, we aimed to evaluate the role of nicotinamide riboside (NR) metabolism in maintaining NAD<sup>+</sup> levels and pancreatic β-cell function in pathophysiological conditions.<h4>Methods</h4>Whole body and pancreatic β-cell-specific NRK1 knockout (KO) mice were metabolically phenotyped in situations of high-fat feeding and aging. We also analyzed pancreatic β-cell function, β-cell mass and gene expression.<h4>Results</h4>W"],"journal":["Molecular metabolism"],"pagination":["101605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9557729"],"repository":["biostudies-literature"],"pubmed_title":["Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure."],"pmcid":["PMC9557729"],"pubmed_authors":["Joffraud M","Zollinger A","Jacot G","Canto C","Metairon S","Ciarlo E","Ratajczak J","Giroud-Gerbetant J","Cercillieux A","Valera-Alberni M","Sambeat A","Rumpler M","Sanchez-Garcia JL"],"additional_accession":[]},"is_claimable":false,"name":"Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure.","description":"<h4>Objective</h4>Disturbances in NAD<sup>+</sup> metabolism have been described as a hallmark for multiple metabolic and age-related diseases, including type 2 diabetes. While alterations in pancreatic β-cell function are critical determinants of whole-body glucose homeostasis, the role of NAD<sup>+</sup> metabolism in the endocrine pancreas remains poorly explored. Here, we aimed to evaluate the role of nicotinamide riboside (NR) metabolism in maintaining NAD<sup>+</sup> levels and pancreatic β-cell function in pathophysiological conditions.<h4>Methods</h4>Whole body and pancreatic β-cell-specific NRK1 knockout (KO) mice were metabolically phenotyped in situations of high-fat feeding and aging. We also analyzed pancreatic β-cell function, β-cell mass and gene expression.<h4>Results</h4>W","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T02:14:12.654Z","creation":"2025-04-05T20:21:08.597Z"},"accession":"S-EPMC9557729","cross_references":{"pubmed":["36165811"],"doi":["10.1016/j.molmet.2022.101605"]}}