{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23"],"submitter":["Bogers SJ"],"pubmed_abstract":["<h4>Background</h4>Indicator-condition (IC) guided HIV testing is a feasible and cost-effective strategy to identify undiagnosed people living with HIV (PLHIV), but remains insufficiently implemented. We aimed to promote IC-guided HIV testing in seven ICs.<h4>Methods</h4>Relevant departments in five hospitals of the Amsterdam region participated. HIV testing among adult patients without known HIV infection but with an IC was assessed using electronic health records during pre-intervention (January 2015-June 2020) and intervention (July 2020-June 2021) periods. The multifaceted intervention included audit and feedback. The primary endpoint was HIV testing ≤3 months before or after IC diagnosis and the effect of the intervention was evaluated using segmented Poisson regression.<h4>Findings</h4>Data from 7986 patients were included, of whom 6730 (84·3%) were diagnosed with an IC in the pre-intervention period and 1256 (15·7%) in the intervention period. The proportion HIV tested ≤3 months before or after IC diagnosis increased from 36.8% to 47.0% (adjusted risk ratio [RR]= 1.16, 95% CI=1.03-1.30, <i>p</i>=0.02). For individual ICs, we observed significant increases in HIV testing among patients with cervical cancer or intraepithelial neoplasia grade 3 (adjusted RR=3.62, 95% CI=1.93-6.79) and peripheral neuropathy (adjusted RR=2.27 95% CI=1.48-3.49), but not the other ICs. Eighteen of 3068 tested patients were HIV positive (0.6%).<h4>Interpretation</h4>Overall IC-guided testing improved after the intervention, but not for all ICs. Variations in effect by IC may have been due to variations in implemented developments, but the effect of separate elements could not be assessed.<h4>Funding</h4>HIV Transmission Elimination Amsterdam (H-TEAM) initiative, Aidsfonds (grant number: P-42702)."],"journal":["The Lancet regional health. Europe"],"pagination":["100515"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9558045"],"repository":["biostudies-literature"],"pubmed_title":["Improving indicator-condition guided testing for HIV in the hospital setting (PROTEST 2·0): A multicenter, interrupted time-series analysis."],"pmcid":["PMC9558045"],"pubmed_authors":["Coyer L","van der Poll T","Jongen V","Woittiez LR","Bruisten S","Reiss P","van Bijnen A","Nobel H","van Zelm MC","Rokx C","Heijnen A","Schouten WEM","de Bree GJ","Schouten J","Ananworanich J","Groot M","Zuilhof W","Brinkman N","Zimmermann HML","van de Beek D","van de Laar TJW","Davidovich U","Mulder J","Brinkman K","Ersan E","Zantkuijl P","Hoornenborg E","Dijkstra M","de Coul ELMO","van Bergen JEAM","Goorhuis A","van der Lubben IM","Koup RA","Mulder BJ","Mouhebati T","van den Berk GEL","Lauw F","Verbon A","van Vugt M","Elsenburg L","de Wit J","Janssen Y","Veenstra J","Bons D","de Vocht J","van Duijnhoven YT","van den Elshout MAM","de Vries HJ","Peters IS","Peters E","Zaheri S","Brokking W","van der Valk M","HIV Transmission Elimination AMsterdam (H-TEAM) Initiative","Deug F","Heidenrijk M","Linde I","Schim van der Loeff MF","Blok WL","Wit FW","Hillebregt MMJ","van der Meer JT","Verdult F","van Agtmael M","de Bruin M","Hommenga M","Kootstra NA","van Gool J","Nijsters A","Boyd A","Geerlings SE","Branger J","Nellen FJ","van Leeuwen MM","Geijtenbeek TBH","van Sighem A","Bezemer D","Prins M","Lettinga K","Vrouenraets S","van Eeden A","Burger D","Ratmann O","Kroon FP","van Benthem T","Bomers M","van Crevel R","Bogers SJ","Bokhizzou N","Wiersinga WJ","Smith D","Loomans DSE","Schat N","Hovius JW","Hankins CA","de Jong K","Felipa PEV","Zakowicz A","Brokx P","Sigaloff K","van der Loeff MFS","Bil JP"],"additional_accession":[]},"is_claimable":false,"name":"Improving indicator-condition guided testing for HIV in the hospital setting (PROTEST 2·0): A multicenter, interrupted time-series analysis.","description":"<h4>Background</h4>Indicator-condition (IC) guided HIV testing is a feasible and cost-effective strategy to identify undiagnosed people living with HIV (PLHIV), but remains insufficiently implemented. We aimed to promote IC-guided HIV testing in seven ICs.<h4>Methods</h4>Relevant departments in five hospitals of the Amsterdam region participated. HIV testing among adult patients without known HIV infection but with an IC was assessed using electronic health records during pre-intervention (January 2015-June 2020) and intervention (July 2020-June 2021) periods. The multifaceted intervention included audit and feedback. The primary endpoint was HIV testing ≤3 months before or after IC diagnosis and the effect of the intervention was evaluated using segmented Poisson regression.<h4>Findings</h4>Data from 7986 patients were included, of whom 6730 (84·3%) were diagnosed with an IC in the pre-intervention period and 1256 (15·7%) in the intervention period. The proportion HIV tested ≤3 months before or after IC diagnosis increased from 36.8% to 47.0% (adjusted risk ratio [RR]= 1.16, 95% CI=1.03-1.30, <i>p</i>=0.02). For individual ICs, we observed significant increases in HIV testing among patients with cervical cancer or intraepithelial neoplasia grade 3 (adjusted RR=3.62, 95% CI=1.93-6.79) and peripheral neuropathy (adjusted RR=2.27 95% CI=1.48-3.49), but not the other ICs. Eighteen of 3068 tested patients were HIV positive (0.6%).<h4>Interpretation</h4>Overall IC-guided testing improved after the intervention, but not for all ICs. Variations in effect by IC may have been due to variations in implemented developments, but the effect of separate elements could not be assessed.<h4>Funding</h4>HIV Transmission Elimination Amsterdam (H-TEAM) initiative, Aidsfonds (grant number: P-42702).","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2024-11-15T06:22:37.478Z","creation":"2024-11-15T06:22:37.478Z"},"accession":"S-EPMC9558045","cross_references":{"pubmed":["36246146"],"doi":["10.1016/j.lanepe.2022.100515"]}}