biostudies-literatureUnknown7(40)Wang RNanotechnology-applied materials and related therapeutics have gained attention for treating inflammatory skin diseases. The beach rose (<i>Rosa rugosa</i>), belonging to the family Rosaceae, is a perennial, deciduous woody shrub endemic to northeastern Asia. In this study, <i>R. rugosa</i>-based gold nanoparticles (RR-AuNPs) were biologically synthesized under optimal conditions to explore their potential as anti-inflammatory agents for treating skin inflammation. The synthesized RR-AuNPs were analyzed using field emission-transmission electron microscopy, energy-dispersive X-ray spectrometry, selected-area electron diffraction, and X-ray diffraction. The uniformly well-structured AuNPs showed near-spherical and polygonal shapes. Cell viability evaluation and optical observation results sACS omega35951-35960https://www.ebi.ac.uk/biostudies/studies/S-EPMC9558598biostudies-literatureBiologically Synthesized <i>Rosa rugosa</i>-Based Gold Nanoparticles Suppress Skin Inflammatory Responses via MAPK and NF-κB Signaling Pathway in TNF-α/IFN-γ-Induced HaCaT Keratinocytes.PMC9558598Kim WJDhandapani SWang RKim HKim YJMoon SKfalseBiologically Synthesized <i>Rosa rugosa</i>-Based Gold Nanoparticles Suppress Skin Inflammatory Responses via MAPK and NF-κB Signaling Pathway in TNF-α/IFN-γ-Induced HaCaT Keratinocytes.Nanotechnology-applied materials and related therapeutics have gained attention for treating inflammatory skin diseases. The beach rose (<i>Rosa rugosa</i>), belonging to the family Rosaceae, is a perennial, deciduous woody shrub endemic to northeastern Asia. In this study, <i>R. rugosa</i>-based gold nanoparticles (RR-AuNPs) were biologically synthesized under optimal conditions to explore their potential as anti-inflammatory agents for treating skin inflammation. The synthesized RR-AuNPs were analyzed using field emission-transmission electron microscopy, energy-dispersive X-ray spectrometry, selected-area electron diffraction, and X-ray diffraction. The uniformly well-structured AuNPs showed near-spherical and polygonal shapes. Cell viability evaluation and optical observation results s2022-01-01T00:00:00Z2022 Oct2025-04-18T22:38:59.273Z2025-04-07T10:27:46.123ZS-EPMC95585983624936210.1021/acsomega.2c04832