{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu L"],"funding":["the Key R&D Project of Shandong Province","Key R&D Project of Shandong Province","Open Project of Liaocheng University Animal Husbandry Discipline","the Open Project of Liaocheng University Animal Husbandry Discipline"],"pagination":["2495"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9559255"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(19)"],"pubmed_abstract":["Equine herpesvirus type 8 (EHV-8), associated with abortion and severe respiratory disease in donkeys and horses, causes significant economic losses in the global equine industry. However, the pathogenicity of EHV-8 is still unknown. Mice are widely used as an animal model to evaluate virus replication and virulence. The present study aimed to evaluate the pathogenicity of the EHV-8 SDLC66 strain in BALB/c mice. Mice were used to test for infection-associated parameters (such as clinical signs, body weights, virus replication in tissues, viremia, and cytokines) and sacrificed at 0, 2, 4, and 6 days post-infection (dpi). The mice inoculated with EHV-8 exhibited lethargy, dyspnea signs, loss in body weight, and viremia. EHV-8 was detected in the liver, spleen, brain, and lung by PCR at 4 dpi"],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["Characterizing the Pathogenesis and Immune Response of Equine Herpesvirus 8 Infection in Lung of Mice."],"pmcid":["PMC9559255"],"funding_grant_id":["319312101-22","319312101-23","319312101-23, 319312101-22","2021TZXD012"],"pubmed_authors":["Ren H","Li Y","Wang C","Wang T","Hu L","Li L","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Characterizing the Pathogenesis and Immune Response of Equine Herpesvirus 8 Infection in Lung of Mice.","description":"Equine herpesvirus type 8 (EHV-8), associated with abortion and severe respiratory disease in donkeys and horses, causes significant economic losses in the global equine industry. However, the pathogenicity of EHV-8 is still unknown. Mice are widely used as an animal model to evaluate virus replication and virulence. The present study aimed to evaluate the pathogenicity of the EHV-8 SDLC66 strain in BALB/c mice. Mice were used to test for infection-associated parameters (such as clinical signs, body weights, virus replication in tissues, viremia, and cytokines) and sacrificed at 0, 2, 4, and 6 days post-infection (dpi). The mice inoculated with EHV-8 exhibited lethargy, dyspnea signs, loss in body weight, and viremia. EHV-8 was detected in the liver, spleen, brain, and lung by PCR at 4 dpi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-04-08T12:08:42.483Z","creation":"2025-04-06T09:23:13.077Z"},"accession":"S-EPMC9559255","cross_references":{"pubmed":["36230234"],"doi":["10.3390/ani12192495"]}}