biostudies-literatureUnknown24(9)Tu SJEarly Career Fellowship from the National Heart Foundation of Australia and the Derek Frewin Lectureship from the University of AdelaideMid-Career Fellowship from the Hospital Research Foundation and a Postdoctoral Fellowship from the National Heart Foundation of AustraliaPostgraduate Scholarship from the Hospital Research FoundationNational Heart Foundation of AustraliaPostdoctoral Fellowship from the University of AdelaidePractitioner Fellowship from the National Health and Medical Research Council of AustraliaEarly Career Fellowship from the National Heart Foundation of AustraliaBeacon Research Fellowship from the University of AdelaideRobert J. Craig Lectureship from the University of Adelaide<h4>Aims</h4>There is a paucity of epidemiological evidence on alcohol and the risk of bradyarrhythmias. We thus characterized associations of total and beverage-specific alcohol consumption with incident bradyarrhythmias using data from the UK Biobank.<h4>Methods and results</h4>Alcohol consumption reported at baseline was calculated as UK standard drinks (8 g alcohol)/week. Bradyarrhythmia events were defined as sinus node dysfunction (SND), high-level atrioventricular block (AVB), and permanent pacemaker implantations. Outcomes were assessed through hospitalization and death records, and dose-response associations were characterized using Cox regression models with correction for regression dilution bias. We studied 407 948 middle-aged individuals (52.4% female). Over a median follow-upEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology1469-1474https://www.ebi.ac.uk/biostudies/studies/S-EPMC9559907biostudies-literatureAlcohol intake and bradyarrhythmia risk: a cohort study of 407 948 individuals.PMC9559907Elliott ADHendriks JMLWong CXTu SJLinz DPitman BMLau DHSanders PGallagher CfalseAlcohol intake and bradyarrhythmia risk: a cohort study of 407 948 individuals.<h4>Aims</h4>There is a paucity of epidemiological evidence on alcohol and the risk of bradyarrhythmias. We thus characterized associations of total and beverage-specific alcohol consumption with incident bradyarrhythmias using data from the UK Biobank.<h4>Methods and results</h4>Alcohol consumption reported at baseline was calculated as UK standard drinks (8 g alcohol)/week. Bradyarrhythmia events were defined as sinus node dysfunction (SND), high-level atrioventricular block (AVB), and permanent pacemaker implantations. Outcomes were assessed through hospitalization and death records, and dose-response associations were characterized using Cox regression models with correction for regression dilution bias. We studied 407 948 middle-aged individuals (52.4% female). Over a median follow-up2022-01-01T00:00:00Z2022 Oct2025-04-27T03:38:36.907Z2025-04-06T18:53:15.42ZS-EPMC95599073517856610.1093/europace/euac007