biostudies-literatureUnknown17(10)Neves RPSeveral studies comparing resistance training (RT) frequencies may have been affected by the large between-subject variability. This study aimed to compare the changes in lower limbs maximal dynamic strength (1RM) and quadriceps femoris cross-sectional area (CSA) after a RT with different weekly frequencies in strength-trained individuals using a within-subject design. Twenty-four men participated in a 9-week RT program, being randomly divided into two conditions: resistance training with equalized total training volume (RTEV) and with unequalized total training volume (RTUV). The RT protocol used the unilateral leg press 45° exercise and each subject's lower limb executed one of the proposed frequencies (one and three times/week). All conditions effectively increased 1RM and CSA (p<0.001)PloS onee0276154https://www.ebi.ac.uk/biostudies/studies/S-EPMC9560172biostudies-literatureEffect of different training frequencies on maximal strength performance and muscle hypertrophy in trained individuals-a within-subject design.PMC9560172Neves RPAihara AYRoschel HVechin FCTeixeira ELda Silva DDUgrinowitsch CTricoli VfalseEffect of different training frequencies on maximal strength performance and muscle hypertrophy in trained individuals-a within-subject design.Several studies comparing resistance training (RT) frequencies may have been affected by the large between-subject variability. This study aimed to compare the changes in lower limbs maximal dynamic strength (1RM) and quadriceps femoris cross-sectional area (CSA) after a RT with different weekly frequencies in strength-trained individuals using a within-subject design. Twenty-four men participated in a 9-week RT program, being randomly divided into two conditions: resistance training with equalized total training volume (RTEV) and with unequalized total training volume (RTUV). The RT protocol used the unilateral leg press 45° exercise and each subject's lower limb executed one of the proposed frequencies (one and three times/week). All conditions effectively increased 1RM and CSA (p<0.001)2022-01-01T00:00:00Z20222025-04-05T20:18:18.129Z2025-04-05T20:18:18.129ZS-EPMC95601723622801610.1371/journal.pone.0276154