{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(9)"],"submitter":["Ling Y"],"pubmed_abstract":["<h4>Background</h4>Genetic epilepsy with febrile seizures plus (GEFS+) is generally considered an ion channelopathy. To date, there have been few studies on inflammation associated with various types of epilepsy, and it remains unclear whether the inflammatory mechanism plays a key role in epilepsy.<h4>Methods</h4>In order to explore the role of the regulatory mechanism of immune factor expression in the pathogenesis of GEFS+, the present study detected the expression level of relevant immune factors such as interleukin-6 (IL-6) in peripheral blood of GEFS+ mice.<h4>Results</h4>The cluster of differentiation 4<sup>+</sup>/cluster of differentiation 8<sup>+</sup> (CD4<sup>+</sup>/CD8<sup>+</sup>) ratio in the GEFS+ mice was decreased, while the signal transducer and activator of transcripti"],"journal":["Translational pediatrics"],"pagination":["1491-1501"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9561518"],"repository":["biostudies-literature"],"pubmed_title":["Mechanism of the promotion of GEFS+ by the STAT3-mediated expression of interleukin-6."],"pmcid":["PMC9561518"],"pubmed_authors":["Yuan C","Ling Y","Jiang X","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Mechanism of the promotion of GEFS+ by the STAT3-mediated expression of interleukin-6.","description":"<h4>Background</h4>Genetic epilepsy with febrile seizures plus (GEFS+) is generally considered an ion channelopathy. To date, there have been few studies on inflammation associated with various types of epilepsy, and it remains unclear whether the inflammatory mechanism plays a key role in epilepsy.<h4>Methods</h4>In order to explore the role of the regulatory mechanism of immune factor expression in the pathogenesis of GEFS+, the present study detected the expression level of relevant immune factors such as interleukin-6 (IL-6) in peripheral blood of GEFS+ mice.<h4>Results</h4>The cluster of differentiation 4<sup>+</sup>/cluster of differentiation 8<sup>+</sup> (CD4<sup>+</sup>/CD8<sup>+</sup>) ratio in the GEFS+ mice was decreased, while the signal transducer and activator of transcripti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-31T09:56:55.816Z","creation":"2024-11-07T03:10:49.707Z"},"accession":"S-EPMC9561518","cross_references":{"pubmed":["36247897"],"doi":["10.21037/tp-22-333"]}}