biostudies-literatureUnknown11(9)Ling Y<h4>Background</h4>Genetic epilepsy with febrile seizures plus (GEFS+) is generally considered an ion channelopathy. To date, there have been few studies on inflammation associated with various types of epilepsy, and it remains unclear whether the inflammatory mechanism plays a key role in epilepsy.<h4>Methods</h4>In order to explore the role of the regulatory mechanism of immune factor expression in the pathogenesis of GEFS+, the present study detected the expression level of relevant immune factors such as interleukin-6 (IL-6) in peripheral blood of GEFS+ mice.<h4>Results</h4>The cluster of differentiation 4⁺/cluster of differentiation 8⁺ (CD4⁺/CD8⁺) ratio in the GEFS+ mice was decreased, while the signal transducer and activator of transcriptiTranslational pediatrics1491-1501https://www.ebi.ac.uk/biostudies/studies/S-EPMC9561518biostudies-literatureMechanism of the promotion of GEFS+ by the STAT3-mediated expression of interleukin-6.PMC9561518Yuan CLing YJiang XWang YfalseMechanism of the promotion of GEFS+ by the STAT3-mediated expression of interleukin-6.<h4>Background</h4>Genetic epilepsy with febrile seizures plus (GEFS+) is generally considered an ion channelopathy. To date, there have been few studies on inflammation associated with various types of epilepsy, and it remains unclear whether the inflammatory mechanism plays a key role in epilepsy.<h4>Methods</h4>In order to explore the role of the regulatory mechanism of immune factor expression in the pathogenesis of GEFS+, the present study detected the expression level of relevant immune factors such as interleukin-6 (IL-6) in peripheral blood of GEFS+ mice.<h4>Results</h4>The cluster of differentiation 4⁺/cluster of differentiation 8⁺ (CD4⁺/CD8⁺) ratio in the GEFS+ mice was decreased, while the signal transducer and activator of transcripti2022-01-01T00:00:00Z2022 Sep2026-05-31T09:56:55.816Z2024-11-07T03:10:49.707ZS-EPMC95615183624789710.21037/tp-22-333