{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["54"],"submitter":["Gong J"],"pubmed_abstract":["<h4>Background</h4>Serum lipid traits are associated with cardiovascular disease, but uncertainty remains regarding their associations with dementia.<h4>Methods</h4>From 2006 to 2010, 254,575 women and 214,891 men were included from the UK Biobank. Cox regression estimated overall and sex-specific hazard ratios (HRs) for apolipoprotein A (ApoA), apolipoprotein B (ApoB), HDL, LDL, total cholesterol, triglycerides, lipoprotein A, and various lipid ratios, by quarters and standard deviation (SD) higher, associated with all-cause dementia, Alzheimer's disease (AD) and vascular dementia (VaD). Subgroup analyses by age and social deprivation were conducted.<h4>Findings</h4>Over 11·8 years (median), 3734 all-cause dementia (1,716 women), 1231 AD and 929 VaD were recorded. Compared to respective l"],"journal":["EClinicalMedicine"],"pagination":["101695"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9561731"],"repository":["biostudies-literature"],"pubmed_title":["Serum lipid traits and the risk of dementia: A cohort study of 254,575 women and 214,891 men in the UK Biobank."],"pmcid":["PMC9561731"],"pubmed_authors":["Peters SAE","Woodward M","Gong J","Harris K"],"additional_accession":[]},"is_claimable":false,"name":"Serum lipid traits and the risk of dementia: A cohort study of 254,575 women and 214,891 men in the UK Biobank.","description":"<h4>Background</h4>Serum lipid traits are associated with cardiovascular disease, but uncertainty remains regarding their associations with dementia.<h4>Methods</h4>From 2006 to 2010, 254,575 women and 214,891 men were included from the UK Biobank. Cox regression estimated overall and sex-specific hazard ratios (HRs) for apolipoprotein A (ApoA), apolipoprotein B (ApoB), HDL, LDL, total cholesterol, triglycerides, lipoprotein A, and various lipid ratios, by quarters and standard deviation (SD) higher, associated with all-cause dementia, Alzheimer's disease (AD) and vascular dementia (VaD). Subgroup analyses by age and social deprivation were conducted.<h4>Findings</h4>Over 11·8 years (median), 3734 all-cause dementia (1,716 women), 1231 AD and 929 VaD were recorded. Compared to respective l","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T06:44:22.738Z","creation":"2025-04-19T06:44:22.738Z"},"accession":"S-EPMC9561731","cross_references":{"pubmed":["36247924"],"doi":["10.1016/j.eclinm.2022.101695"]}}