biostudies-literatureUnknown54Gong J<h4>Background</h4>Serum lipid traits are associated with cardiovascular disease, but uncertainty remains regarding their associations with dementia.<h4>Methods</h4>From 2006 to 2010, 254,575 women and 214,891 men were included from the UK Biobank. Cox regression estimated overall and sex-specific hazard ratios (HRs) for apolipoprotein A (ApoA), apolipoprotein B (ApoB), HDL, LDL, total cholesterol, triglycerides, lipoprotein A, and various lipid ratios, by quarters and standard deviation (SD) higher, associated with all-cause dementia, Alzheimer's disease (AD) and vascular dementia (VaD). Subgroup analyses by age and social deprivation were conducted.<h4>Findings</h4>Over 11·8 years (median), 3734 all-cause dementia (1,716 women), 1231 AD and 929 VaD were recorded. Compared to respective lEClinicalMedicine101695https://www.ebi.ac.uk/biostudies/studies/S-EPMC9561731biostudies-literatureSerum lipid traits and the risk of dementia: A cohort study of 254,575 women and 214,891 men in the UK Biobank.PMC9561731Peters SAEWoodward MGong JHarris KfalseSerum lipid traits and the risk of dementia: A cohort study of 254,575 women and 214,891 men in the UK Biobank.<h4>Background</h4>Serum lipid traits are associated with cardiovascular disease, but uncertainty remains regarding their associations with dementia.<h4>Methods</h4>From 2006 to 2010, 254,575 women and 214,891 men were included from the UK Biobank. Cox regression estimated overall and sex-specific hazard ratios (HRs) for apolipoprotein A (ApoA), apolipoprotein B (ApoB), HDL, LDL, total cholesterol, triglycerides, lipoprotein A, and various lipid ratios, by quarters and standard deviation (SD) higher, associated with all-cause dementia, Alzheimer's disease (AD) and vascular dementia (VaD). Subgroup analyses by age and social deprivation were conducted.<h4>Findings</h4>Over 11·8 years (median), 3734 all-cause dementia (1,716 women), 1231 AD and 929 VaD were recorded. Compared to respective l2022-01-01T00:00:00Z2022 Dec2025-04-19T06:44:22.738Z2025-04-19T06:44:22.738ZS-EPMC95617313624792410.1016/j.eclinm.2022.101695