{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cho WW"],"funding":["National Research Foundation of Korea"],"pagination":["e2202093"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9561777"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(29)"],"pubmed_abstract":["Although metastatic melanoma can be managed with chemotherapy, its heterogeneity and resistance to therapy remain poorly understood. In addition to the spread of melanoma in the bloodstream, melanoma-stroma interaction and the lymphatic system play active roles in said heterogeneity and resistance, leading to its progression and metastasis. Reproducing the complexities of the melanoma microenvironment in vitro will help understanding its progression and enhance the translatability of potential cancer therapeutics. A blood-lymphatic integrated system with heterogeneous melanoma spheroids (BLISH) using the in-bath bioprinting process is developed. The process uniformly prints size-controllable metastatic melanoma spheroids along with biomimetic blood and lymphatic vessels (LVs). The system r"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Blood-Lymphatic Integrated System with Heterogeneous Melanoma Spheroids via In-Bath Three-Dimensional Bioprinting for Modelling of Combinational Targeted Therapy."],"pmcid":["PMC9561777"],"funding_grant_id":["2022R1A5A2027161","2020M3H4A1A02084827"],"pubmed_authors":["Ahn M","Cho WW","Kim BS","Cho DW"],"additional_accession":[]},"is_claimable":false,"name":"Blood-Lymphatic Integrated System with Heterogeneous Melanoma Spheroids via In-Bath Three-Dimensional Bioprinting for Modelling of Combinational Targeted Therapy.","description":"Although metastatic melanoma can be managed with chemotherapy, its heterogeneity and resistance to therapy remain poorly understood. In addition to the spread of melanoma in the bloodstream, melanoma-stroma interaction and the lymphatic system play active roles in said heterogeneity and resistance, leading to its progression and metastasis. Reproducing the complexities of the melanoma microenvironment in vitro will help understanding its progression and enhance the translatability of potential cancer therapeutics. A blood-lymphatic integrated system with heterogeneous melanoma spheroids (BLISH) using the in-bath bioprinting process is developed. The process uniformly prints size-controllable metastatic melanoma spheroids along with biomimetic blood and lymphatic vessels (LVs). The system r","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-19T06:42:58.63Z","creation":"2024-11-13T10:06:54.044Z"},"accession":"S-EPMC9561777","cross_references":{"pubmed":["36026581"],"doi":["10.1002/advs.202202093"]}}