{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mausoleo A"],"funding":["Villa M","MSDAVENIR","Agence Nationale de Recherches sur le Sida et les Hépatites Virales"],"pagination":["3104"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9561982"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(19)"],"pubmed_abstract":["During chronic SIV/HIV infection, adipose tissue (AT) is the target of both antiretroviral treatment (ART) and the virus. AT might subsequently contribute to the low-grade systemic inflammation observed in patients on ART. To evaluate the inflammatory profile of AT during chronic SIV/HIV infection, we assayed subcutaneous and visceral abdominal AT from non-infected (SIV-, control), ART-naïve SIV-infected (SIV+) and ART-controlled SIV-infected (SIV+ART+) cynomolgus macaques for the mRNA expression of genes coding for factors related to inflammation. Significant differences were observed only when comparing the SIV+ART+ group with the SIV+ and/or SIV- groups. ART-treated infection impacted the metabolic fraction (with elevated expression of PPARγ and CEBPα), the extracellular matrix (with el"],"journal":["Cells"],"pubmed_title":["Prolonged Antiretroviral Treatment Induces Adipose Tissue Remodelling Associated with Mild Inflammation in SIV-Infected Macaques."],"pmcid":["PMC9561982"],"funding_grant_id":["Fonds de Dotation","grant to the RHIVIERA consortium","ECTZ103291"],"pubmed_authors":["Olivo A","Desjardins D","Bereziat V","Avettand-Fenoel V","Noel N","Le Grand R","Bourgeois C","Saez-Cirion A","Barrail-Tran A","Lagathu C","Mausoleo A","Lambotte O"],"additional_accession":[]},"is_claimable":false,"name":"Prolonged Antiretroviral Treatment Induces Adipose Tissue Remodelling Associated with Mild Inflammation in SIV-Infected Macaques.","description":"During chronic SIV/HIV infection, adipose tissue (AT) is the target of both antiretroviral treatment (ART) and the virus. AT might subsequently contribute to the low-grade systemic inflammation observed in patients on ART. To evaluate the inflammatory profile of AT during chronic SIV/HIV infection, we assayed subcutaneous and visceral abdominal AT from non-infected (SIV-, control), ART-naïve SIV-infected (SIV+) and ART-controlled SIV-infected (SIV+ART+) cynomolgus macaques for the mRNA expression of genes coding for factors related to inflammation. Significant differences were observed only when comparing the SIV+ART+ group with the SIV+ and/or SIV- groups. ART-treated infection impacted the metabolic fraction (with elevated expression of PPARγ and CEBPα), the extracellular matrix (with el","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-03T22:33:11.576Z","creation":"2024-10-16T02:41:27.608Z"},"accession":"S-EPMC9561982","cross_references":{"pubmed":["36231066"],"doi":["10.3390/cells11193104"]}}