{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Timsina J"],"funding":["NIA NIH HHS"],"pagination":["193-207"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9562128"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["89(1)"],"pubmed_abstract":["<h4>Background</h4>The SOMAscan assay has an advantage over immunoassay-based methods because it measures a large number of proteins in a cost-effective manner. However, the performance of this technology compared to the routinely used immunoassay techniques needs to be evaluated.<h4>Objective</h4>We performed comparative analyses of SOMAscan and immunoassay-based protein measurements for five cerebrospinal fluid (CSF) proteins associated with Alzheimer's disease (AD) and neurodegeneration: NfL, Neurogranin, sTREM2, VILIP-1, and SNAP-25.<h4>Methods</h4>We compared biomarkers measured in ADNI (N = 689), Knight-ADRC (N = 870), DIAN (N = 115), and Barcelona-1 (N = 92) cohorts. Raw protein values were transformed using z-score in order to combine measures from the different studies. sTREM2 and"],"journal":["Journal of Alzheimer's disease : JAD"],"pubmed_title":["Comparative Analysis of Alzheimer's Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach."],"pmcid":["PMC9562128"],"funding_grant_id":["R01 AG057777","R01 AG044546","P30 AG066444","U01 AG058922","RF1 AG074007","U01 AG024904","P01 AG026276","RF1 AG058501","U19 AG032438","P01 AG003991","RF1 AG053303"],"pubmed_authors":["Fagan AM","Gomez-Fonseca D","Bateman RJ","Aguilar M","Wang L","Alzheimer’s Disease Neuroimaging Initiative","Schindler SE","Dominantly Inherited Alzheimer Network Consortia","Farlow M","Mori H","Perrin RJ","Sung YJ","Alvarez I","Herries E","Timsina J","Hassenstab J","Pastor P","Do A","Western D","Morris JC","Moulder K","Cruchaga C","Henson RL","Xiong C","Voglein J","Chhatwal J"],"additional_accession":[]},"is_claimable":false,"name":"Comparative Analysis of Alzheimer's Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach.","description":"<h4>Background</h4>The SOMAscan assay has an advantage over immunoassay-based methods because it measures a large number of proteins in a cost-effective manner. However, the performance of this technology compared to the routinely used immunoassay techniques needs to be evaluated.<h4>Objective</h4>We performed comparative analyses of SOMAscan and immunoassay-based protein measurements for five cerebrospinal fluid (CSF) proteins associated with Alzheimer's disease (AD) and neurodegeneration: NfL, Neurogranin, sTREM2, VILIP-1, and SNAP-25.<h4>Methods</h4>We compared biomarkers measured in ADNI (N = 689), Knight-ADRC (N = 870), DIAN (N = 115), and Barcelona-1 (N = 92) cohorts. Raw protein values were transformed using z-score in order to combine measures from the different studies. sTREM2 and","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-04T05:56:18.588Z","creation":"2026-05-06T03:08:03.394Z"},"accession":"S-EPMC9562128","cross_references":{"pubmed":["35871346"],"doi":["10.3233/jad-220399","10.3233/JAD-220399"]}}