biostudies-literatureUnknown11(19)Carlini LSeveral studies have shown that mammalian retinal rod outer segments (OS) are peculiar structures devoid of mitochondria, characterized by ectopic expression of the molecular machinery for oxidative phosphorylation. Such ectopic aerobic metabolism would provide the chemical energy for the phototransduction taking place in the OS. Natural polyphenols include a large variety of molecules having pleiotropic effects, ranging from anti-inflammatory to antioxidant and others. Our goal in the present study was to investigate the potential of the flavonoid cirsiliol, a trihydroxy-6,7-dimethoxyflavone extracted from <i>Salvia x jamensis</i>, in modulating reactive oxygen species production by the ectopic oxidative phosphorylation taking place in the OS. Our molecular docking analysis identified cirCells3169https://www.ebi.ac.uk/biostudies/studies/S-EPMC9562182biostudies-literatureThe Flavone Cirsiliol from <i>Salvia x jamensis</i> Binds the F₁ Moiety of ATP Synthase, Modulating Free Radical Production.PMC9562182Tancreda GEsposito AManni LSchito ACarlini LBruno SPanfoli ICalzia DIobbi VTraverso CECaicci FBisio ARavera SBenini SfalseThe Flavone Cirsiliol from <i>Salvia x jamensis</i> Binds the F₁ Moiety of ATP Synthase, Modulating Free Radical Production.Several studies have shown that mammalian retinal rod outer segments (OS) are peculiar structures devoid of mitochondria, characterized by ectopic expression of the molecular machinery for oxidative phosphorylation. Such ectopic aerobic metabolism would provide the chemical energy for the phototransduction taking place in the OS. Natural polyphenols include a large variety of molecules having pleiotropic effects, ranging from anti-inflammatory to antioxidant and others. Our goal in the present study was to investigate the potential of the flavonoid cirsiliol, a trihydroxy-6,7-dimethoxyflavone extracted from <i>Salvia x jamensis</i>, in modulating reactive oxygen species production by the ectopic oxidative phosphorylation taking place in the OS. Our molecular docking analysis identified cir2022-01-01T00:00:00Z2022 Oct2026-04-08T11:54:57.007Z2024-12-03T20:17:11.444ZS-EPMC95621823623113110.3390/cells11193169