{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(19)"],"submitter":["Krasniqi E"],"funding":["IRCCS Regina Elena National Cancer Institute, Ricerca Corrente 2015"],"pubmed_abstract":["The Hippo pathway and its two key effectors, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), are consistently altered in breast cancer. Pivotal regulators of cell metabolism such as the AMP-activated protein kinase (AMPK), Stearoyl-CoA-desaturase 1 (SCD1), and HMG-CoA reductase (HMGCR) are relevant modulators of TAZ/YAP activity. In this prospective study, we measured the tumor expression of TAZ, YAP, AMPK, SCD1, and HMGCR by immunohistochemistry in 65 Her2+ breast cancer patients who underwent trastuzumab-based neoadjuvant treatment. The aim of the study was to assess the impact of the immunohistochemical expression of the Hippo pathway transducers and cell metabolism regulators on pathological complete response. Low expression of cytoplasmic TAZ"],"journal":["Cancers"],"pagination":["4835"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9563553"],"repository":["biostudies-literature"],"pubmed_title":["The Impact of the Hippo Pathway and Cell Metabolism on Pathological Complete Response in Locally Advanced Her2+ Breast Cancer: The TRISKELE Multicenter Prospective Study."],"pmcid":["PMC9563553"],"pubmed_authors":["Cappuzzo F","Gamucci T","Santini D","Barba M","Cavicchi F","Maugeri-Sacca M","Sperati F","Ercolani C","Pizzuti L","Grassadonia A","Marchetti P","D'Auria G","Filomeno L","Montemurro F","Krasniqi E","Minelli M","Vici P","Botti C","Ciliberto G","Sanguineti G","Pelle F","Di Lisa FS","De Maria R","Botticelli A","Tomao S","Di Benedetto A","Cappelli S","Mazzotta M","Fabbri MA","Tinari N"],"additional_accession":[]},"is_claimable":false,"name":"The Impact of the Hippo Pathway and Cell Metabolism on Pathological Complete Response in Locally Advanced Her2+ Breast Cancer: The TRISKELE Multicenter Prospective Study.","description":"The Hippo pathway and its two key effectors, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), are consistently altered in breast cancer. Pivotal regulators of cell metabolism such as the AMP-activated protein kinase (AMPK), Stearoyl-CoA-desaturase 1 (SCD1), and HMG-CoA reductase (HMGCR) are relevant modulators of TAZ/YAP activity. In this prospective study, we measured the tumor expression of TAZ, YAP, AMPK, SCD1, and HMGCR by immunohistochemistry in 65 Her2+ breast cancer patients who underwent trastuzumab-based neoadjuvant treatment. The aim of the study was to assess the impact of the immunohistochemical expression of the Hippo pathway transducers and cell metabolism regulators on pathological complete response. Low expression of cytoplasmic TAZ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-08-31T03:10:58.697Z","creation":"2024-11-13T10:12:47.972Z"},"accession":"S-EPMC9563553","cross_references":{"pubmed":["36230758"],"doi":["10.3390/cancers14194835"]}}