biostudies-literatureUnknown101(5)Olthof EP<h4>Introduction</h4>To establish the impact of the number of lymph node metastases (nLNM) and the lymph node ratio (LNR) on survival in patients with early-stage cervical cancer after surgery.<h4>Material and methods</h4>In this nationwide historical cohort study, all women diagnosed between 1995 and 2020 with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA2-IIA1 cervical cancer and nodal metastases after radical hysterectomy and pelvic lymphadenectomy from the Netherlands Cancer Registry were selected. Optimal cut-offs for prognostic stratification by nLNM and LNR were calculated to categorize patients into low-risk or high-risk groups. Kaplan-Meier overall survival analysis and flexible parametric relative survival analysis were used to determine the impact ofActa obstetricia et gynecologica Scandinavica550-557https://www.ebi.ac.uk/biostudies/studies/S-EPMC9564443biostudies-literatureThe prognostic value of the number of positive lymph nodes and the lymph node ratio in early-stage cervical cancer.PMC9564443Olthof EPvan der Velden Jvan der Aa MAMom CHWenzel HHBSnijders MLHfalseThe prognostic value of the number of positive lymph nodes and the lymph node ratio in early-stage cervical cancer.<h4>Introduction</h4>To establish the impact of the number of lymph node metastases (nLNM) and the lymph node ratio (LNR) on survival in patients with early-stage cervical cancer after surgery.<h4>Material and methods</h4>In this nationwide historical cohort study, all women diagnosed between 1995 and 2020 with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA2-IIA1 cervical cancer and nodal metastases after radical hysterectomy and pelvic lymphadenectomy from the Netherlands Cancer Registry were selected. Optimal cut-offs for prognostic stratification by nLNM and LNR were calculated to categorize patients into low-risk or high-risk groups. Kaplan-Meier overall survival analysis and flexible parametric relative survival analysis were used to determine the impact of2022-01-01T00:00:00Z2022 May2025-04-05T11:49:07.946Z2025-04-05T11:49:07.946ZS-EPMC95644433521820510.1111/aogs.14316