biostudies-literatureXing SNational Natural Science Foundation of China12555https://www.ebi.ac.uk/biostudies/studies/S-EPMC9566264biostudies-literatureUnknown19(19)Rhamnolipids, a type of biosurfactant, represent a potential strategy for both enhancing organismic resistance and in situ remediation of heavy metals contaminations. In-depth study of the mechanism of rhamnolipids synthesis in response to heavy metals stress, is indispensable for a wide use of biosurfactant-secreting microbes in bioremediation. In this study, we employed the wild-type and the <i>rhlAB</i> deficient strain (Δ<i>rhlAB</i>) of <i>Pseudomonas aeruginosa</i>, a prototypal rhamnolipids-producing soil microorganism, to investigate its responses to cadmium resistance based on its physicochemical, and physiological properties. Compared with the wild-type strain, the Δ<i>rhlAB</i> were more sensitive to Cd-stress at low Cd concentration (&lt;50 mg/L), whereas there was little diffeInternational journal of environmental research and public healthLimited Role of Rhamnolipids on Cadmium Resistance for an Endogenous-Secretion Bacterium.PMC9566264U20A20146, 21808127Yan ZTian HWang SXing SSong CfalseLimited Role of Rhamnolipids on Cadmium Resistance for an Endogenous-Secretion Bacterium.Rhamnolipids, a type of biosurfactant, represent a potential strategy for both enhancing organismic resistance and in situ remediation of heavy metals contaminations. In-depth study of the mechanism of rhamnolipids synthesis in response to heavy metals stress, is indispensable for a wide use of biosurfactant-secreting microbes in bioremediation. In this study, we employed the wild-type and the <i>rhlAB</i> deficient strain (Δ<i>rhlAB</i>) of <i>Pseudomonas aeruginosa</i>, a prototypal rhamnolipids-producing soil microorganism, to investigate its responses to cadmium resistance based on its physicochemical, and physiological properties. Compared with the wild-type strain, the Δ<i>rhlAB</i> were more sensitive to Cd-stress at low Cd concentration (&lt;50 mg/L), whereas there was little diffe2022-01-01T00:00:00Z2022 Oct2025-04-04T23:03:10.47Z2024-12-04T01:59:33.621ZS-EPMC95662643623185710.3390/ijerph191912555