{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sauer JF"],"funding":["Deutsche Forschungsgemeinschaft","European Research Council"],"pagination":["e79471"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9566853"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["We interrogated prefrontal circuit function in mice lacking <i>Disrupted-in-schizophrenia-1</i> (Disc1-mutant mice), a risk factor for psychiatric disorders. Single-unit recordings in awake mice revealed reduced average firing rates of fast-spiking interneurons (INTs), including optogenetically identified parvalbumin-positive cells, and a lower proportion of INTs phase-coupled to ongoing gamma oscillations. Moreover, we observed decreased spike transmission efficacy at local pyramidal cell (PYR)-INT connections in vivo, suggesting a reduced excitatory effect of local glutamatergic inputs as a potential mechanism of lower INT rates. On the network level, impaired INT function resulted in altered activation of PYR assemblies: While assembly activations defined as coactivations within 25 ms were observed equally often, the expression strength of individual assembly patterns was significantly higher in Disc1-mutant mice. Our data, thus, reveal a role of Disc1 in shaping the properties of prefrontal assembly patterns by setting INT responsiveness to glutamatergic drive."],"journal":["eLife"],"pubmed_title":["<i>Disrupted-in-schizophrenia-1</i> is required for normal pyramidal cell-interneuron communication and assembly dynamics in the prefrontal cortex."],"pmcid":["PMC9566853"],"funding_grant_id":["787450","ERC-AdG787450","FOR2143-2","FOR5159 TP7","BA1582/2-2","SA3609/1-1"],"pubmed_authors":["Sauer JF","Bartos M"],"additional_accession":[]},"is_claimable":false,"name":"<i>Disrupted-in-schizophrenia-1</i> is required for normal pyramidal cell-interneuron communication and assembly dynamics in the prefrontal cortex.","description":"We interrogated prefrontal circuit function in mice lacking <i>Disrupted-in-schizophrenia-1</i> (Disc1-mutant mice), a risk factor for psychiatric disorders. Single-unit recordings in awake mice revealed reduced average firing rates of fast-spiking interneurons (INTs), including optogenetically identified parvalbumin-positive cells, and a lower proportion of INTs phase-coupled to ongoing gamma oscillations. Moreover, we observed decreased spike transmission efficacy at local pyramidal cell (PYR)-INT connections in vivo, suggesting a reduced excitatory effect of local glutamatergic inputs as a potential mechanism of lower INT rates. On the network level, impaired INT function resulted in altered activation of PYR assemblies: While assembly activations defined as coactivations within 25 ms were observed equally often, the expression strength of individual assembly patterns was significantly higher in Disc1-mutant mice. Our data, thus, reveal a role of Disc1 in shaping the properties of prefrontal assembly patterns by setting INT responsiveness to glutamatergic drive.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-26T22:09:05.565Z","creation":"2025-04-06T17:04:52.556Z"},"accession":"S-EPMC9566853","cross_references":{"pubmed":["36239988"],"doi":["10.7554/eLife.79471"]}}