{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeong HW"],"funding":["University of Münster and the German Research Foundation","Cluster of Excellence 'Cells in Motion'","Max-Planck-Gesellschaft"],"pagination":["e57520"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9566870"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS). While BBB defects are a hallmark of many neurological disorders, the cellular heterogeneity at the neurovascular interface, and the mechanisms governing neuroinflammation are not fully understood.Through single-cell RNA sequencing of non-neuronal cell populations of the murine cerebral cortex during development, adulthood, ageing, and neuroinflammation, we identify reactive endothelial venules, a compartment of specialized postcapillary endothelial cells that are characterized by consistent expression of cell adhesion molecules, preferential leukocyte transmigration, association with perivascular macrophage populations, and endothelial "],"journal":["eLife"],"pubmed_title":["Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain."],"pmcid":["PMC9566870"],"funding_grant_id":["CRC1366A01","SO285/11-1","CRC1009A02","EXC1003"],"pubmed_authors":["Dieguez-Hurtado R","Jeong HW","Park H","Arf H","Sorokin L","Adams RH","Kruse K","Song J"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain.","description":"The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS). While BBB defects are a hallmark of many neurological disorders, the cellular heterogeneity at the neurovascular interface, and the mechanisms governing neuroinflammation are not fully understood.Through single-cell RNA sequencing of non-neuronal cell populations of the murine cerebral cortex during development, adulthood, ageing, and neuroinflammation, we identify reactive endothelial venules, a compartment of specialized postcapillary endothelial cells that are characterized by consistent expression of cell adhesion molecules, preferential leukocyte transmigration, association with perivascular macrophage populations, and endothelial ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-06-20T03:24:20.496Z","creation":"2025-04-06T00:14:34.264Z"},"accession":"S-EPMC9566870","cross_references":{"pubmed":["36197007"],"doi":["10.7554/eLife.57520"]}}