{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Teixeira Junior AAL"],"funding":["Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão"],"pagination":["1063"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9569053"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Although penile cancer (PC) is uncommon in developed countries, it is widespread in developing countries. The state of Maranhão (Northeast, Brazil) has the highest global incidence recorded for PC, and, despite its socioeconomic vulnerability, it has been attributed to human papillomavirus (HPV) infection. This study aimed to determine the histopathological features, the prevalence of HPV infection, and the immunohistochemical profile of PC in Maranhão.<h4>Methods</h4>A retrospective cohort of 200 PC cases were evaluated. HPV detection was performed using nested-PCR followed by direct sequencing for genotyping. Immunohistochemistry (IHC) was performed using monoclonal antibodies anti-p16<sup>INK4a</sup>, p53, and ki-67.<h4>Results</h4>Our data revealed a delay of 17 mont"],"journal":["BMC cancer"],"pubmed_title":["A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease."],"pmcid":["PMC9569053"],"funding_grant_id":["01339/17 and 01184/19"],"pubmed_authors":["de Ribamar Rodrigues Calixto J","Araujo WS","Paiva Paiva LC","Khayat AS","Duarte KG","Alencar Junior AM","da Graca Carvalhal Frazao Correa R","Silva GEB","Rocha TMS","de Castro Belfort MR","da Costa Melo SP","Sobrinho TBM","de Oliveira Barbosa L","Pinho JD","Dos Reis RB","do Nascimento FSMS","Lages JS","Duarte WE","Teixeira Junior AAL","da Silva Neto AL","Duarte DRD"],"additional_accession":[]},"is_claimable":false,"name":"A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease.","description":"<h4>Background</h4>Although penile cancer (PC) is uncommon in developed countries, it is widespread in developing countries. The state of Maranhão (Northeast, Brazil) has the highest global incidence recorded for PC, and, despite its socioeconomic vulnerability, it has been attributed to human papillomavirus (HPV) infection. This study aimed to determine the histopathological features, the prevalence of HPV infection, and the immunohistochemical profile of PC in Maranhão.<h4>Methods</h4>A retrospective cohort of 200 PC cases were evaluated. HPV detection was performed using nested-PCR followed by direct sequencing for genotyping. Immunohistochemistry (IHC) was performed using monoclonal antibodies anti-p16<sup>INK4a</sup>, p53, and ki-67.<h4>Results</h4>Our data revealed a delay of 17 mont","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T09:30:41.527Z","creation":"2025-04-04T09:30:41.527Z"},"accession":"S-EPMC9569053","cross_references":{"pubmed":["36243680"],"doi":["10.1186/s12885-022-10127-z"]}}