{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Ooya T"],"pubmed_abstract":["(+)-Catechin conjugated with human serum albumin (CT-HSA) was prepared and evaluated as a drug carrier bearing anticancer effects. It was found that 2.4 mol of CT was conjugate to 1 mol HSA. The CT-HSA has an antioxidant capacity of about 3.3 times the amount of CT in the conjugate. Intracellular incorporation of the CT-HSA was analyzed by fluorescence-activated cell sorting (FACS) and confocal laser scanning microscopy (CLSM) measurements using fluorescein isothiocyanate (FITC)-labelled CT-HSA. The results indicated that the FITC-labelled CT-HSA was incorporated into HeLa cells in a concentration-dependent manner. The CT-HSA enhanced the binding of anticancer drugs (5-fluorouracil (5-Fu) and mitomycin C (MMC)) comparing with HSA, and the CT-HSA mixed with 5-Fu or MMC decreased significant"],"journal":["International journal of food science"],"pagination":["1596687"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9569216"],"repository":["biostudies-literature"],"pubmed_title":["Catechin-Albumin Conjugates: Enhanced Antioxidant Capacity and Anticancer Effects."],"pmcid":["PMC9569216"],"pubmed_authors":["Haraguchi I","Ooya T"],"additional_accession":[]},"is_claimable":false,"name":"Catechin-Albumin Conjugates: Enhanced Antioxidant Capacity and Anticancer Effects.","description":"(+)-Catechin conjugated with human serum albumin (CT-HSA) was prepared and evaluated as a drug carrier bearing anticancer effects. It was found that 2.4 mol of CT was conjugate to 1 mol HSA. The CT-HSA has an antioxidant capacity of about 3.3 times the amount of CT in the conjugate. Intracellular incorporation of the CT-HSA was analyzed by fluorescence-activated cell sorting (FACS) and confocal laser scanning microscopy (CLSM) measurements using fluorescein isothiocyanate (FITC)-labelled CT-HSA. The results indicated that the FITC-labelled CT-HSA was incorporated into HeLa cells in a concentration-dependent manner. The CT-HSA enhanced the binding of anticancer drugs (5-fluorouracil (5-Fu) and mitomycin C (MMC)) comparing with HSA, and the CT-HSA mixed with 5-Fu or MMC decreased significant","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-20T01:50:15.347Z","creation":"2025-04-20T01:50:15.347Z"},"accession":"S-EPMC9569216","cross_references":{"pubmed":["36254123"],"doi":["10.1155/2022/1596687"]}}