biostudies-literatureUnknown2022Zhao L<h4>Background</h4>Aging leads to vascular endothelial cell senescence. Decreased expression of VEGFA and VEGFR2 plays a crucial role in impairing angiogenesis in senescent endothelial cells. Noncoding RNAs, including circular RNAs (circRNAs) and microRNAs (miRNAs), regulate endothelial cell proliferation, differentiation, apoptosis, and migration and participate in the occurrence and development of vascular diseases. However, the mechanism of noncoding RNAs in age-related vascular endothelial dysfunction remains unclear. Here, we aimed to identify the circRNA that is associated with VEGF/VEGFR2 signaling pathway activation in angiogenesis.<h4>Methods</h4>Immunoblotting, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), <i>in vitro</i> and <i>in vivo</i> experiments, Oxidative medicine and cellular longevity2062885https://www.ebi.ac.uk/biostudies/studies/S-EPMC9569221biostudies-literatureCircCRIM1 Ameliorates Endothelial Cell Angiogenesis in Aging through the miR-455-3p/Twist1/VEGFR2 Signaling Axis.PMC9569221Qiu JZhao LHuang YHu ZWang SCui JLian CZhu XChen RWang JfalseCircCRIM1 Ameliorates Endothelial Cell Angiogenesis in Aging through the miR-455-3p/Twist1/VEGFR2 Signaling Axis.<h4>Background</h4>Aging leads to vascular endothelial cell senescence. Decreased expression of VEGFA and VEGFR2 plays a crucial role in impairing angiogenesis in senescent endothelial cells. Noncoding RNAs, including circular RNAs (circRNAs) and microRNAs (miRNAs), regulate endothelial cell proliferation, differentiation, apoptosis, and migration and participate in the occurrence and development of vascular diseases. However, the mechanism of noncoding RNAs in age-related vascular endothelial dysfunction remains unclear. Here, we aimed to identify the circRNA that is associated with VEGF/VEGFR2 signaling pathway activation in angiogenesis.<h4>Methods</h4>Immunoblotting, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), <i>in vitro</i> and <i>in vivo</i> experiments, 2022-01-01T00:00:00Z20222025-04-18T19:31:51.656Z2025-04-07T07:13:33.703ZS-EPMC95692213625423110.1155/2022/2062885