biostudies-literatureSilva FFVEMinisterio de Ciencia e Innovación of the Spanish government11937https://www.ebi.ac.uk/biostudies/studies/S-EPMC9569947biostudies-literatureUnknown23(19)Head and neck cancer (HNC) is an ascending and agressive disease. The search for new molecular markers is emerging to solve difficulties in diagnosis, risk management, prognosis and effectiveness of treatments. Proteins related to apoptotic machinery have been identified as potential biomarkers. Caspase 3 is the main effector caspase and has a key role in apoptosis. The objective of this systematic review and meta-analysis is to review studies that analyze changes in Caspase 3 and Cleaved Caspase 3 expression both in oral premalignant disorders (OPMD) as well as in head and neck cancer (HNC). This study also proposes to review the prognostic values associated with HNC according to the expression of Caspase 3. Medline (via PubMed), EMBASE, Scopus, Cochrane, Web of Science and Grey LiteraturInternational journal of molecular sciencesCaspase 3 and Cleaved Caspase 3 Expression in Tumorogenesis and Its Correlations with Prognosis in Head and Neck Cancer: A Systematic Review and Meta-Analysis.PMC9569947PID2020-118101GBI00 and PID2020-116587GBI00 and ERDFSuarez-Penaranda JChamorro-Petronacci CMPerez-Sayans MCaponio VCAPadin-Iruegas MESilva FFVESaavedra-Nieves PLorenzo-Pouso AIfalseCaspase 3 and Cleaved Caspase 3 Expression in Tumorogenesis and Its Correlations with Prognosis in Head and Neck Cancer: A Systematic Review and Meta-Analysis.Head and neck cancer (HNC) is an ascending and agressive disease. The search for new molecular markers is emerging to solve difficulties in diagnosis, risk management, prognosis and effectiveness of treatments. Proteins related to apoptotic machinery have been identified as potential biomarkers. Caspase 3 is the main effector caspase and has a key role in apoptosis. The objective of this systematic review and meta-analysis is to review studies that analyze changes in Caspase 3 and Cleaved Caspase 3 expression both in oral premalignant disorders (OPMD) as well as in head and neck cancer (HNC). This study also proposes to review the prognostic values associated with HNC according to the expression of Caspase 3. Medline (via PubMed), EMBASE, Scopus, Cochrane, Web of Science and Grey Literatur2022-01-01T00:00:00Z2022 Oct2026-06-20T03:16:40.73Z2024-11-13T10:09:56.302ZS-EPMC95699473623324210.3390/ijms231911937