biostudies-literatureGaspar LMFundação para a Ciência e Tecnologia11749https://www.ebi.ac.uk/biostudies/studies/S-EPMC9570112biostudies-literatureUnknown23(19)The majority of pituitary adenomas occur in a sporadic context, and in the absence of known genetic predisposition. Three common variants at the <i>NEBL</i> (rs2359536), <i>PCDH15</i> (rs10763170) and <i>CDK8</i> (rs17083838) loci were previously associated with sporadic pituitary adenomas in the Han Chinese population, but these findings have not yet been replicated in any other population. The aim of this case-control study was to assess if these variants are associated with susceptibility to sporadic pituitary adenomas in the Portuguese population. Genotype and allele frequencies were determined in 570 cases and in 546 controls. The <i>CDK8</i> rs17083838 minor allele (A allele) was significantly associated with sporadic pituitary adenomas, under an additive (odds ratio (OR) 1.73, 95% cInternational journal of molecular sciencesA Common Variant in the <i>CDK8</i> Gene Is Associated with Sporadic Pituitary Adenomas in the Portuguese Population: A Case-Control Study.PMC9570112PTDC/MEC-MET/29489/2017UIDB/00709/2020SFRH/BD/147160/2019Lemos MCAmaral CGoncalves CICarvalho DBarros IFPalha ACortez LNobre EBugalho MJGaspar LMFonseca FDuarte JSPereira BDMarques OfalseA Common Variant in the <i>CDK8</i> Gene Is Associated with Sporadic Pituitary Adenomas in the Portuguese Population: A Case-Control Study.The majority of pituitary adenomas occur in a sporadic context, and in the absence of known genetic predisposition. Three common variants at the <i>NEBL</i> (rs2359536), <i>PCDH15</i> (rs10763170) and <i>CDK8</i> (rs17083838) loci were previously associated with sporadic pituitary adenomas in the Han Chinese population, but these findings have not yet been replicated in any other population. The aim of this case-control study was to assess if these variants are associated with susceptibility to sporadic pituitary adenomas in the Portuguese population. Genotype and allele frequencies were determined in 570 cases and in 546 controls. The <i>CDK8</i> rs17083838 minor allele (A allele) was significantly associated with sporadic pituitary adenomas, under an additive (odds ratio (OR) 1.73, 95% c2022-01-01T00:00:00Z2022 Oct2025-04-04T07:52:12.254Z2024-11-15T22:40:13.972ZS-EPMC95701123623305010.3390/ijms231911749