{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Costa VD"],"funding":["CSIC Grupos-908 I+D","ANII","CAP","CSIC Iniciación","Comisión Sectorial de Investigación Científica","Agencia Nacional de Investigación e Innovación","PEDECIBA"],"pagination":["12047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9570357"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(19)"],"pubmed_abstract":["Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of <i>N</i>-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the <i>O</i>-glycosylation pathways that influenced the interaction with mouse M"],"journal":["International journal of molecular sciences"],"pubmed_title":["Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties."],"pmcid":["PMC9570357"],"funding_grant_id":["FCE1-2017-1-136094","Grupos-908 I+D","to Teresa Freire and Valeria da Costa","CSIC-Iniciación","ID114"],"pubmed_authors":["Rodriguez-Zraquia SA","Marino KV","Lores P","Costa VD","Costa M","Rabinovich GA","Freire T","Landeira M","Festari MF","van Vliet SJ"],"additional_accession":[]},"is_claimable":false,"name":"Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties.","description":"Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of <i>N</i>-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the <i>O</i>-glycosylation pathways that influenced the interaction with mouse M","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T09:29:57.596Z","creation":"2024-11-06T04:34:13.733Z"},"accession":"S-EPMC9570357","cross_references":{"pubmed":["36233358"],"doi":["10.3390/ijms231912047"]}}