{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Katagiri W"],"funding":["Keio University","National Institute of Neurological Disorders and Stroke","National Institute of Allergy and Infectious Diseases","Massachusetts General Hospital","NIAID NIH HHS","Keidanren","NINDS NIH HHS","Terumo"],"pagination":["e22521"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9574655"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(10)"],"pubmed_abstract":["Immunotherapy, including immune checkpoint inhibitors, has revolutionized cancer treatment, but only a minor fraction of patients shows durable responses. A new approach to overcome this limitation is yet to be identified. Recently, we have shown that photobiomodulation (PBM) with near-infrared (NIR) light in the NIR-II window reduces oxidative stress and supports the proliferation of CD8<sup>+</sup> T cells, suggesting that PBM with NIR-II light could augment anti-cancer immunity. Here, we report a novel approach to support tumor-infiltrating CD8<sup>+</sup> T cells upon PBM with NIR-II laser with high tissue penetration depth. Brief treatments of a murine model of breast cancer with dual 1064 and 1270 nm lasers reduced the expression of the programmed cell death protein 1 (PD-1) in CD8<s"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy."],"pmcid":["PMC9574655"],"funding_grant_id":["R01 NS096237","R01NS096237","R21AI144103","R01AI105131","R01 AI105131","R21 AI144103"],"pubmed_authors":["Iwasaki T","Monaco H","Atochin DN","Katagiri W","Sato A","Ogawa E","Feil S","Roessing M","Manganiello S","Choi HS","Fukuda T","Fukumura D","Kashiwagi S","Kopp T","Ng MR","Yokomizo S","Ishizuka T","Yamashita K","Sato H","Nomura S"],"additional_accession":[]},"is_claimable":false,"name":"Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy.","description":"Immunotherapy, including immune checkpoint inhibitors, has revolutionized cancer treatment, but only a minor fraction of patients shows durable responses. A new approach to overcome this limitation is yet to be identified. Recently, we have shown that photobiomodulation (PBM) with near-infrared (NIR) light in the NIR-II window reduces oxidative stress and supports the proliferation of CD8<sup>+</sup> T cells, suggesting that PBM with NIR-II light could augment anti-cancer immunity. Here, we report a novel approach to support tumor-infiltrating CD8<sup>+</sup> T cells upon PBM with NIR-II laser with high tissue penetration depth. Brief treatments of a murine model of breast cancer with dual 1064 and 1270 nm lasers reduced the expression of the programmed cell death protein 1 (PD-1) in CD8<s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-25T21:27:51.973Z","creation":"2025-04-06T08:44:21.256Z"},"accession":"S-EPMC9574655","cross_references":{"pubmed":["36052742"],"doi":["10.1096/fj.202200033R","10.1096/fj.202200033r"]}}