{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Corrales WA"],"funding":["National Institute of Environmental Health Sciences","Intramural NIH HHS","Fondo Nacional de Desarrollo Científico y Tecnológico"],"pagination":["2981-3001"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9575153"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(16)"],"pubmed_abstract":["We explored sex-biased effects of the primary stress glucocorticoid hormone corticosterone on the miRNA expression profile in the rat hippocampus. Adult adrenalectomized (ADX) female and male rats received a single corticosterone (10 mg/kg) or vehicle injection, and after 6 h, hippocampi were collected for miRNA, mRNA, and Western blot analyses. miRNA profiling microarrays showed a basal sex-biased miRNA profile in ADX rat hippocampi. Additionally, acute corticosterone administration triggered a sex-biased differential expression of miRNAs derived from genes located in several chromosomes and clusters on the X and 6 chromosomes. Putative promoter analysis unveiled that most corticosterone-responsive miRNA genes contained motifs for either direct or indirect glucocorticoid actions in both s"],"journal":["ACS chemical neuroscience"],"pubmed_title":["Sex-Dependent Changes of miRNA Levels in the Hippocampus of Adrenalectomized Rats Following Acute Corticosterone Administration."],"pmcid":["PMC9575153"],"funding_grant_id":["ZIA ES090057","Z01 ES090057","1190899","ZIC ES102445","ZIC ES102546"],"pubmed_authors":["Silva JP","Aliaga E","Rojas PS","Maracaja-Coutinho V","Avalos AM","Aguayo FI","Cidlowski JA","Venegas-Zamora L","Fiedler JL","Roman-Albasini L","Oakley RH","Parra CS","Olave FA","Corrales WA"],"additional_accession":[]},"is_claimable":false,"name":"Sex-Dependent Changes of miRNA Levels in the Hippocampus of Adrenalectomized Rats Following Acute Corticosterone Administration.","description":"We explored sex-biased effects of the primary stress glucocorticoid hormone corticosterone on the miRNA expression profile in the rat hippocampus. Adult adrenalectomized (ADX) female and male rats received a single corticosterone (10 mg/kg) or vehicle injection, and after 6 h, hippocampi were collected for miRNA, mRNA, and Western blot analyses. miRNA profiling microarrays showed a basal sex-biased miRNA profile in ADX rat hippocampi. Additionally, acute corticosterone administration triggered a sex-biased differential expression of miRNAs derived from genes located in several chromosomes and clusters on the X and 6 chromosomes. Putative promoter analysis unveiled that most corticosterone-responsive miRNA genes contained motifs for either direct or indirect glucocorticoid actions in both s","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T22:44:51.558Z","creation":"2025-04-04T22:44:51.558Z"},"accession":"S-EPMC9575153","cross_references":{"pubmed":["34339164"],"doi":["10.1021/acschemneuro.0c00762"]}}