{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Verma R"],"funding":["BLRD VA","National Center for Research Resources","NIBIB NIH HHS","NCRR NIH HHS","National Cancer Institute","NCI NIH HHS","National Institute of Biomedical Imaging and Bioengineering"],"pagination":["1115-1123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9575418"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(8)"],"pubmed_abstract":["<h4>Background and purpose</h4>Glioblastoma is an aggressive brain tumor, with no validated prognostic biomarkers for survival before surgical resection. Although recent approaches have demonstrated the prognostic ability of tumor habitat (constituting necrotic core, enhancing lesion, T2/FLAIR hyperintensity subcompartments) derived radiomic features for glioblastoma survival on treatment-naive MR imaging scans, radiomic features are known to be sensitive to MR imaging acquisitions across sites and scanners. In this study, we sought to identify the radiomic features that are both stable across sites and discriminatory of poor and improved progression-free survival in glioblastoma tumors.<h4>Materials and methods</h4>We used 150 treatment-naive glioblastoma MR imaging scans (Gadolinium-T1w,"],"journal":["AJNR. American journal of neuroradiology"],"pubmed_title":["Stable and Discriminatory Radiomic Features from the Tumor and Its Habitat Associated with Progression-Free Survival in Glioblastoma: A Multi-Institutional Study."],"pmcid":["PMC9575418"],"funding_grant_id":["1R43EB028736-01","R01 CA216579-01A1","C06 RR012463","R43 EB028736","R01 CA216579","U01 CA248226","1 C06 RR12463-01","1U01CA248226-01","1U01 CA239055-01","I01 BX004121","R01 CA220581-01A1","U24 CA199374","U01 CA239055","R01 CA220581","R01 CA202752","R01CA202752-01A1","1U24CA199374-01","R01 CA264017","R01 CA208236","R01CA208236-01A1"],"pubmed_authors":["Verma R","Leo P","Tiwari P","Bera K","Ahluwalia M","Hill VB","Correa R","Statsevych V","Madabhushi A"],"additional_accession":[]},"is_claimable":false,"name":"Stable and Discriminatory Radiomic Features from the Tumor and Its Habitat Associated with Progression-Free Survival in Glioblastoma: A Multi-Institutional Study.","description":"<h4>Background and purpose</h4>Glioblastoma is an aggressive brain tumor, with no validated prognostic biomarkers for survival before surgical resection. Although recent approaches have demonstrated the prognostic ability of tumor habitat (constituting necrotic core, enhancing lesion, T2/FLAIR hyperintensity subcompartments) derived radiomic features for glioblastoma survival on treatment-naive MR imaging scans, radiomic features are known to be sensitive to MR imaging acquisitions across sites and scanners. In this study, we sought to identify the radiomic features that are both stable across sites and discriminatory of poor and improved progression-free survival in glioblastoma tumors.<h4>Materials and methods</h4>We used 150 treatment-naive glioblastoma MR imaging scans (Gadolinium-T1w,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-05T12:27:19.742Z","creation":"2024-11-15T03:19:21.67Z"},"accession":"S-EPMC9575418","cross_references":{"pubmed":["36920774"],"doi":["10.3174/ajnr.a7591","10.3174/ajnr.A7591"]}}