{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(10)"],"submitter":["Yin Z"],"pubmed_abstract":["<h4>Background</h4>To date, almost all studies regarding chimeric antigen receptor (CAR)-T cell therapy for B-cell acute lymphoblastic leukemia (B-ALL) were performed in refractory/relapsed (r/r) or minimal residual disease-positive patients. CAR-T therapy in remission patients has not been reported.<h4>Aim</h4>To observe the treatment outcome of CAR-T cells for remission B-ALL patients with poor prognosis.<h4>Methods and results</h4>CAR-T treatment was applied to two B-ALL patients in remission status who had poor prognostic factors and refused transplantation, and one case was unable to accept standard chemotherapy owing to multiple complications. The procedure of CAR-T therapy in these two remission patients was the same as that in r/r B-ALL patients. Lentiviral vectors encoding second "],"journal":["Cancer reports (Hoboken, N.J.)"],"pagination":["e1706"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9575491"],"repository":["biostudies-literature"],"pubmed_title":["CAR-T therapy as a consolidation in remission B-ALL patients with poor prognosis."],"pmcid":["PMC9575491"],"pubmed_authors":["Tong C","Lin Y","Liu S","Liu D","Yin Z"],"additional_accession":[]},"is_claimable":false,"name":"CAR-T therapy as a consolidation in remission B-ALL patients with poor prognosis.","description":"<h4>Background</h4>To date, almost all studies regarding chimeric antigen receptor (CAR)-T cell therapy for B-cell acute lymphoblastic leukemia (B-ALL) were performed in refractory/relapsed (r/r) or minimal residual disease-positive patients. CAR-T therapy in remission patients has not been reported.<h4>Aim</h4>To observe the treatment outcome of CAR-T cells for remission B-ALL patients with poor prognosis.<h4>Methods and results</h4>CAR-T treatment was applied to two B-ALL patients in remission status who had poor prognostic factors and refused transplantation, and one case was unable to accept standard chemotherapy owing to multiple complications. The procedure of CAR-T therapy in these two remission patients was the same as that in r/r B-ALL patients. Lentiviral vectors encoding second ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T22:55:19.464Z","creation":"2025-04-07T10:41:07.336Z"},"accession":"S-EPMC9575491","cross_references":{"pubmed":["35995579"],"doi":["10.1002/cnr2.1706"]}}