biostudies-literatureUnknown5(10)Yin Z<h4>Background</h4>To date, almost all studies regarding chimeric antigen receptor (CAR)-T cell therapy for B-cell acute lymphoblastic leukemia (B-ALL) were performed in refractory/relapsed (r/r) or minimal residual disease-positive patients. CAR-T therapy in remission patients has not been reported.<h4>Aim</h4>To observe the treatment outcome of CAR-T cells for remission B-ALL patients with poor prognosis.<h4>Methods and results</h4>CAR-T treatment was applied to two B-ALL patients in remission status who had poor prognostic factors and refused transplantation, and one case was unable to accept standard chemotherapy owing to multiple complications. The procedure of CAR-T therapy in these two remission patients was the same as that in r/r B-ALL patients. Lentiviral vectors encoding second Cancer reports (Hoboken, N.J.)e1706https://www.ebi.ac.uk/biostudies/studies/S-EPMC9575491biostudies-literatureCAR-T therapy as a consolidation in remission B-ALL patients with poor prognosis.PMC9575491Tong CLin YLiu SLiu DYin ZfalseCAR-T therapy as a consolidation in remission B-ALL patients with poor prognosis.<h4>Background</h4>To date, almost all studies regarding chimeric antigen receptor (CAR)-T cell therapy for B-cell acute lymphoblastic leukemia (B-ALL) were performed in refractory/relapsed (r/r) or minimal residual disease-positive patients. CAR-T therapy in remission patients has not been reported.<h4>Aim</h4>To observe the treatment outcome of CAR-T cells for remission B-ALL patients with poor prognosis.<h4>Methods and results</h4>CAR-T treatment was applied to two B-ALL patients in remission status who had poor prognostic factors and refused transplantation, and one case was unable to accept standard chemotherapy owing to multiple complications. The procedure of CAR-T therapy in these two remission patients was the same as that in r/r B-ALL patients. Lentiviral vectors encoding second 2022-01-01T00:00:00Z2022 Oct2025-04-18T22:55:19.464Z2025-04-07T10:41:07.336ZS-EPMC95754913599557910.1002/cnr2.1706