biostudies-literatureUnknown43(10)Laflamme MStryker educational grant<h4>Background and purpose</h4>The quality of leptomeningeal collaterals may influence the speed of infarct progression in acute stroke. Our main objective was to evaluate the association of leptomeningeal collateral score and its interaction with time with ischemic changes on CT in patients with acute stroke.<h4>Materials and methods</h4>Adult patients with acute stroke symptoms and anterior circulation large-vessel occlusion on CTA from 2015 to 2019 were included. Routinely performed NCCT and multiphase CTA were reviewed to assess ASPECTS and the leptomeningeal collateral score. We built multivariate regression models to assess the association between leptomeningeal collateral score and its interaction with time and ASPECTS. Performance measures to predict poor ASPECTS at different time AJNR. American journal of neuroradiology1424-1430https://www.ebi.ac.uk/biostudies/studies/S-EPMC9575540biostudies-literatureAssociation between Early Ischemic Changes and Collaterals in Acute Stroke: A Retrospective Study.PMC9575540Camden MCLaflamme MGariepy CSimonyan DLavoie PValdes MMAudet MEVerreault SGariepy JLCarrondo-Cottin SfalseAssociation between Early Ischemic Changes and Collaterals in Acute Stroke: A Retrospective Study.<h4>Background and purpose</h4>The quality of leptomeningeal collaterals may influence the speed of infarct progression in acute stroke. Our main objective was to evaluate the association of leptomeningeal collateral score and its interaction with time with ischemic changes on CT in patients with acute stroke.<h4>Materials and methods</h4>Adult patients with acute stroke symptoms and anterior circulation large-vessel occlusion on CTA from 2015 to 2019 were included. Routinely performed NCCT and multiphase CTA were reviewed to assess ASPECTS and the leptomeningeal collateral score. We built multivariate regression models to assess the association between leptomeningeal collateral score and its interaction with time and ASPECTS. Performance measures to predict poor ASPECTS at different time 2022-01-01T00:00:00Z2022 Oct2025-04-25T21:30:49.751Z2025-04-06T08:42:46.853ZS-EPMC95755403613765610.3174/ajnr.a763210.3174/ajnr.A7632